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- W2076750100 abstract "Although the etiology of preeclampsia is unknown, accumulated evidence suggests that the expression of a variety of syncytiotrophoblast transporters is reduced or abnormal. Here, we have examined the expression of NHE-3 in preeclamptic placentas. We found that NHE-3 expression significantly decreased and its labeling was almost undetectable in the cytosol of syncytiotrophoblast cells. Even though the inductor mechanisms of NHE-3 decrease are not clear yet, we speculated that alterations in TNF-α and aldosterone levels observed in preeclampsia might be downregulating NHE-3 expression. Further studies are needed to define whether these alterations play a direct role either in the pathogenesis or in the adaptative response of preeclampsia." @default.
- W2076750100 created "2016-06-24" @default.
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- W2076750100 date "2013-09-01" @default.
- W2076750100 modified "2023-10-05" @default.
- W2076750100 title "Reduced expression of Na(+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas" @default.
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- W2076750100 doi "https://doi.org/10.1016/j.placenta.2013.06.005" @default.
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