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• W2076752271 endingPage "746" @default.
• W2076752271 startingPage "742" @default.
• W2076752271 abstract "Pseudomonas aeruginosa is a human pathogen, which causes infections of various organs, including lung, skin and eye, particularly in individuals who are immunocompromised. Pyocyanin (1-hydroxy-5-methylphenazine), a cytotoxic pigment secreted by the bacterium, is among the factors that contribute to virulence of this pathogen. We have previously shown that rose bengal and riboflavin photosensitize oxidation of pyocyanin to a product(s) with diminished reactivity and toxicity. Singlet oxygen was suggested as the major oxidant, based on the inhibitory effect of sodium azide. In the present study, we used the time resolved technique to investigate direct interaction of pyocyanin and related phenazines (1-hydroxyphenazine [1-OH-Phen], 1-methoxy-5-methylphenazine [1-MeO-PCN] and phenazine methosulfate [PMS]) with (1)O(2). The rate constants for the (1)O(2) quenching (physical + chemical) by pyocyanin and 1-OH-Phen in D(2)O buffer (pD approximately 7.2) have been determined to be 4.8 x 10(8) and 6.8 x 10(8) M(-1) s(-1), respectively. 1-MeO-PCN and PMS were markedly less efficient (1)O(2) quenchers. Among the phenazines studied only phenazine methosulfate photogenerated (1)O(2) (Phi((1)O(2)) = 0.56 in acetonitrile). Interaction of (1)O(2) with pyocyanin and other related phenazines produced by the bacteria may be important in determining the potential utility of photochemical/pharmacological approaches to eradicate P. aeruginosa from infected tissues." @default.
• W2076752271 created "2016-06-24" @default.
• W2076752271 creator A5002881154 @default.
• W2076752271 creator A5020414606 @default.
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• W2076752271 date "2010-07-01" @default.
• W2076752271 modified "2023-10-15" @default.
• W2076752271 title "Quenching of Singlet Oxygen by Pyocyanin and Related Phenazines^†" @default.
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• W2076752271 doi "https://doi.org/10.1111/j.1751-1097.2010.00728.x" @default.
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