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• W2076752705 abstract "Summary 1.Serum protein analyses by paper electrophoresis on twenty-three children with leukemia have been presented. 2.Normal serum protein patterns were frequently observed. Variations from normal consisted of low albumin and gamma globulin and occasionally an increase in alpha1 and alpha2 globulins in patients with acute lymphocytic leukemia. In acute myelogenous leukemia a decrease in the albumin fraction and an increase in alpha1 and alpha2 globulins occurred. A low albumin and beta globulin and occasional elevation of the alpha2 globulin were sometimes seen in patients with chronic myelocytic leukemia. The one patient studied with chronic lymphocytic leukemia showed a normal serum protein pattern. 3.The mean values for each serum protein constituent in each group of leukemia patients studied fell within the normal range; however, wide variations from the mean plus or minus (±) 1.96 standard deviations of the mean were encountered. 4.No direct correlation could be made between the alteration of serum protein constituents and the drugs employed in the therapy of these patients except for a decrease in the albumin fraction during steroid therapy. 5.Alterations in the normal serum protein fractions in patients with leukemia is probably of a nonspecific nature and may be related to tissue destruction, fever, or infection. 6.Changes in the electrophoretic serum protein components in the present study were of little value in the diagnosis of leukemia; however, the presence of abnormal patterns may lead one to suspect a relapse and progression of the disease. Summary 1.Serum protein analyses by paper electrophoresis on twenty-three children with leukemia have been presented. 2.Normal serum protein patterns were frequently observed. Variations from normal consisted of low albumin and gamma globulin and occasionally an increase in alpha1 and alpha2 globulins in patients with acute lymphocytic leukemia. In acute myelogenous leukemia a decrease in the albumin fraction and an increase in alpha1 and alpha2 globulins occurred. A low albumin and beta globulin and occasional elevation of the alpha2 globulin were sometimes seen in patients with chronic myelocytic leukemia. The one patient studied with chronic lymphocytic leukemia showed a normal serum protein pattern. 3.The mean values for each serum protein constituent in each group of leukemia patients studied fell within the normal range; however, wide variations from the mean plus or minus (±) 1.96 standard deviations of the mean were encountered. 4.No direct correlation could be made between the alteration of serum protein constituents and the drugs employed in the therapy of these patients except for a decrease in the albumin fraction during steroid therapy. 5.Alterations in the normal serum protein fractions in patients with leukemia is probably of a nonspecific nature and may be related to tissue destruction, fever, or infection. 6.Changes in the electrophoretic serum protein components in the present study were of little value in the diagnosis of leukemia; however, the presence of abnormal patterns may lead one to suspect a relapse and progression of the disease." @default.
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• W2076752705 date "1957-09-01" @default.
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• W2076752705 title "Paper electrophoretic study of serum proteins in children with leukemia" @default.
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• W2076752705 doi "https://doi.org/10.1016/s0022-3476(57)80198-x" @default.
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