Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076754622> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2076754622 endingPage "2628" @default.
- W2076754622 startingPage "2617" @default.
- W2076754622 abstract "The retinal chromophore (11Z)-3-diazo-4-oxoretinal (1) with two photo-labile moieties has been synthesized by semi-hydrogenation of an 11-yne precursor with activated Zn in aqueous media. Incorporation of 1 into opsin yielded diazoketo rhodopsin (DK-Rh), which, upon bleaching, gave rise to intermediates batho-Rh, lumi-Rh, meta-Rh, and meta-II-Rh corresponding to those of native Rh but at lower temperatures. Photoaffinity labeling of DK-Rh and these bleaching intermediates showed that the ionone ring cross-linked to Trp265 of helix F in DK-Rh and batho intermediate, and to Ala169 of helix D in lumi, meta-I, and meta-II intermediates. These results demonstrate the occurrence of large conformational changes along the visual transduction path, which, in turn, is responsible for activation of the G-protein." @default.
- W2076754622 created "2016-06-24" @default.
- W2076754622 creator A5003245401 @default.
- W2076754622 creator A5034790721 @default.
- W2076754622 creator A5052952898 @default.
- W2076754622 creator A5077947899 @default.
- W2076754622 date "2000-09-06" @default.
- W2076754622 modified "2023-10-17" @default.
- W2076754622 title "Synthesis of a Photoaffinity-Labeled (11Z)-Retinal: Identification of Retinal/Rhodopsin Cross-Linked Sites along the Visual-Transduction Path" @default.
- W2076754622 doi "https://doi.org/10.1002/1522-2675(20000906)83:9<2617::aid-hlca2617>3.0.co;2-9" @default.
- W2076754622 hasPublicationYear "2000" @default.
- W2076754622 type Work @default.
- W2076754622 sameAs 2076754622 @default.
- W2076754622 citedByCount "15" @default.
- W2076754622 countsByYear W20767546222012 @default.
- W2076754622 crossrefType "journal-article" @default.
- W2076754622 hasAuthorship W2076754622A5003245401 @default.
- W2076754622 hasAuthorship W2076754622A5034790721 @default.
- W2076754622 hasAuthorship W2076754622A5052952898 @default.
- W2076754622 hasAuthorship W2076754622A5077947899 @default.
- W2076754622 hasConcept C107824862 @default.
- W2076754622 hasConcept C131667965 @default.
- W2076754622 hasConcept C178790620 @default.
- W2076754622 hasConcept C185592680 @default.
- W2076754622 hasConcept C192468462 @default.
- W2076754622 hasConcept C202033177 @default.
- W2076754622 hasConcept C2778581200 @default.
- W2076754622 hasConcept C2780378348 @default.
- W2076754622 hasConcept C2780827179 @default.
- W2076754622 hasConcept C30028475 @default.
- W2076754622 hasConcept C55493867 @default.
- W2076754622 hasConcept C71240020 @default.
- W2076754622 hasConcept C75473681 @default.
- W2076754622 hasConceptScore W2076754622C107824862 @default.
- W2076754622 hasConceptScore W2076754622C131667965 @default.
- W2076754622 hasConceptScore W2076754622C178790620 @default.
- W2076754622 hasConceptScore W2076754622C185592680 @default.
- W2076754622 hasConceptScore W2076754622C192468462 @default.
- W2076754622 hasConceptScore W2076754622C202033177 @default.
- W2076754622 hasConceptScore W2076754622C2778581200 @default.
- W2076754622 hasConceptScore W2076754622C2780378348 @default.
- W2076754622 hasConceptScore W2076754622C2780827179 @default.
- W2076754622 hasConceptScore W2076754622C30028475 @default.
- W2076754622 hasConceptScore W2076754622C55493867 @default.
- W2076754622 hasConceptScore W2076754622C71240020 @default.
- W2076754622 hasConceptScore W2076754622C75473681 @default.
- W2076754622 hasIssue "9" @default.
- W2076754622 hasLocation W20767546221 @default.
- W2076754622 hasOpenAccess W2076754622 @default.
- W2076754622 hasPrimaryLocation W20767546221 @default.
- W2076754622 hasRelatedWork W1603853902 @default.
- W2076754622 hasRelatedWork W1982146585 @default.
- W2076754622 hasRelatedWork W2002839850 @default.
- W2076754622 hasRelatedWork W2017793896 @default.
- W2076754622 hasRelatedWork W2035961823 @default.
- W2076754622 hasRelatedWork W2057204549 @default.
- W2076754622 hasRelatedWork W2094253653 @default.
- W2076754622 hasRelatedWork W2104313455 @default.
- W2076754622 hasRelatedWork W2163132804 @default.
- W2076754622 hasRelatedWork W2529764422 @default.
- W2076754622 hasVolume "83" @default.
- W2076754622 isParatext "false" @default.
- W2076754622 isRetracted "false" @default.
- W2076754622 magId "2076754622" @default.
- W2076754622 workType "article" @default.