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- W2076756139 abstract "The antiproliferative activity of aconitylated (AIFN) and succinylated (SIFN) derivatives of recombinant interferon- alpha2b (IFN-alpha2b) was examined. Acylation of IFN-alpha2b was performed by succinic and cis-aconitic anhydrides. Antiproliferative properties of AIFN and SIFN were studied in vitro on the CaOv cell line, highly sensitive to IFN, and on the SW-480 cell line, with low sensitivity to IFN-alpha2b. Acylation of one lysine in the IFN-alpha2b molecule with cis-aconitic or succinic anhydride resulted in a 3-3.5-fold increase of its antiproliferative activity on CaOv cells. The highest antiproliferative activity of acylated IFN-alpha2b on SW-480 cells was observed for both AIFNs and SIFNs with three modified lysine residues. In conclusion, aconitylated and succinylated IFNs may be useful antiproliferative agents for cancer treatment." @default.
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- W2076756139 date "2005-07-01" @default.
- W2076756139 modified "2023-09-23" @default.
- W2076756139 title "Antiproliferative Properties of Chemically Modified Recombinant IFN-α2b" @default.
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- W2076756139 doi "https://doi.org/10.1089/jir.2005.25.414" @default.
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