FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076759214> ?p ?o ?g. }

• W2076759214 endingPage "589" @default.
• W2076759214 startingPage "581" @default.
• W2076759214 abstract "Abeta (amyloid-beta peptides) generated by proteolysis of APP (beta-amyloid precursor protein), play an important role in the pathogenesis of AD (Alzheimer's disease). ER (endoplasmic reticulum) chaperones, such as GRP78 (glucose-regulated protein 78), make a major contribution to protein quality control in the ER. In the present study, we examined the effect of overexpression of various ER chaperones on the production of Abeta in cultured cells, which produce a mutant type of APP (APPsw). Overexpression of GRP78 or inhibition of its basal expression, decreased and increased respectively the level of Abeta40 and Abeta42 in conditioned medium. Co-expression of GRP78's co-chaperones ERdj3 or ERdj4 stimulated this inhibitory effect of GRP78. In the case of the other ER chaperones, overexpression of some (150 kDa oxygen-regulated protein and calnexin) but not others (GRP94 and calreticulin) suppressed the production of Abeta. These results indicate that certain ER chaperones are effective suppressors of Abeta production and that non-toxic inducers of ER chaperones may be therapeutically beneficial for AD treatment. GRP78 was co-immunoprecipitated with APP and overexpression of GRP78 inhibited the maturation of APP, suggesting that GRP78 binds directly to APP and inhibits its maturation, resulting in suppression of the proteolysis of APP. On the other hand, overproduction of APPsw or addition of synthetic Abeta42 caused up-regulation of the mRNA of various ER chaperones in cells. Furthermore, in the cortex and hippocampus of transgenic mice expressing APPsw, the mRNA of some ER chaperones was up-regulated in comparison with wild-type mice. We consider that this up-regulation is a cellular protective response against Abeta." @default.
• W2076759214 created "2016-06-24" @default.
• W2076759214 creator A5000541947 @default.
• W2076759214 creator A5004738239 @default.
• W2076759214 creator A5007583494 @default.
• W2076759214 creator A5043150882 @default.
• W2076759214 creator A5057535269 @default.
• W2076759214 creator A5065167441 @default.
• W2076759214 date "2007-02-26" @default.
• W2076759214 modified "2023-10-17" @default.
• W2076759214 title "Endoplasmic reticulum chaperones inhibit the production of amyloid-β peptides" @default.
• W2076759214 cites W1494703029 @default.
• W2076759214 cites W1541961513 @default.
• W2076759214 cites W1566528879 @default.
• W2076759214 cites W1608735237 @default.
• W2076759214 cites W185139613 @default.
• W2076759214 cites W1911014954 @default.
• W2076759214 cites W1964822121 @default.
• W2076759214 cites W1966655072 @default.
• W2076759214 cites W1978999653 @default.
• W2076759214 cites W1979164049 @default.
• W2076759214 cites W1983996266 @default.
• W2076759214 cites W1984672567 @default.
• W2076759214 cites W1988986946 @default.
• W2076759214 cites W1995344309 @default.
• W2076759214 cites W1998026822 @default.
• W2076759214 cites W2002439304 @default.
• W2076759214 cites W2004782459 @default.
• W2076759214 cites W2007922488 @default.
• W2076759214 cites W2010436550 @default.
• W2076759214 cites W2016692750 @default.
• W2076759214 cites W2017406246 @default.
• W2076759214 cites W2018046986 @default.
• W2076759214 cites W2023531011 @default.
• W2076759214 cites W2042794149 @default.
• W2076759214 cites W2044235576 @default.
• W2076759214 cites W2047201865 @default.
• W2076759214 cites W2050030183 @default.
• W2076759214 cites W2051561353 @default.
• W2076759214 cites W2057709960 @default.
• W2076759214 cites W2064507821 @default.
• W2076759214 cites W2071407428 @default.
• W2076759214 cites W2074593513 @default.
• W2076759214 cites W2080274663 @default.
• W2076759214 cites W2082429191 @default.
• W2076759214 cites W2090839709 @default.
• W2076759214 cites W2091835577 @default.
• W2076759214 cites W2094597369 @default.
• W2076759214 cites W2095704733 @default.
• W2076759214 cites W2096410114 @default.
• W2076759214 cites W2101884100 @default.
• W2076759214 cites W2102537613 @default.
• W2076759214 cites W2117037463 @default.
• W2076759214 cites W2126800086 @default.
• W2076759214 cites W2127848114 @default.
• W2076759214 cites W2129412868 @default.
• W2076759214 cites W2140882575 @default.
• W2076759214 cites W2144859756 @default.
• W2076759214 cites W2145112854 @default.
• W2076759214 cites W2152398979 @default.
• W2076759214 cites W2162076197 @default.
• W2076759214 cites W2162690000 @default.
• W2076759214 cites W2169404909 @default.
• W2076759214 cites W4248136323 @default.
• W2076759214 cites W4250374989 @default.
• W2076759214 doi "https://doi.org/10.1042/bj20061318" @default.
• W2076759214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1863563" @default.
• W2076759214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17132139" @default.
• W2076759214 hasPublicationYear "2007" @default.
• W2076759214 type Work @default.
• W2076759214 sameAs 2076759214 @default.
• W2076759214 citedByCount "108" @default.
• W2076759214 countsByYear W20767592142012 @default.
• W2076759214 countsByYear W20767592142013 @default.
• W2076759214 countsByYear W20767592142014 @default.
• W2076759214 countsByYear W20767592142015 @default.
• W2076759214 countsByYear W20767592142016 @default.
• W2076759214 countsByYear W20767592142017 @default.
• W2076759214 countsByYear W20767592142018 @default.
• W2076759214 countsByYear W20767592142019 @default.
• W2076759214 countsByYear W20767592142020 @default.
• W2076759214 countsByYear W20767592142021 @default.
• W2076759214 countsByYear W20767592142022 @default.
• W2076759214 countsByYear W20767592142023 @default.
• W2076759214 crossrefType "journal-article" @default.
• W2076759214 hasAuthorship W2076759214A5000541947 @default.
• W2076759214 hasAuthorship W2076759214A5004738239 @default.
• W2076759214 hasAuthorship W2076759214A5007583494 @default.
• W2076759214 hasAuthorship W2076759214A5043150882 @default.
• W2076759214 hasAuthorship W2076759214A5057535269 @default.
• W2076759214 hasAuthorship W2076759214A5065167441 @default.
• W2076759214 hasBestOaLocation W20767592142 @default.
• W2076759214 hasConcept C126322002 @default.
• W2076759214 hasConcept C130361206 @default.
• W2076759214 hasConcept C139447449 @default.
• W2076759214 hasConcept C142724271 @default.
• W2076759214 hasConcept C153911025 @default.
• W2076759214 hasConcept C158617107 @default.

• next