Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076759566> ?p ?o ?g. }
- W2076759566 endingPage "801" @default.
- W2076759566 startingPage "794" @default.
- W2076759566 abstract "Since delusional disorder is characterized by mono-symptomatic paranoid symptoms, it can be a good clinical model for investigating the dopaminergic mechanism responsible for paranoid symptoms. We examined neuroleptic responses, plasma homovanillic acid (pHVA) and genes of the dopamine receptor (DR) and its synthesizing enzyme (tyrosine hydroxylase: TH) in patients with delusional disorder and compared them with those of schizophrenic patients and healthy controls. Results: (1) A relatively small dose of haloperidol was more effective for delusional disorder than for schizophrenia. (2) The pretreatment level of pHVA was higher in patients with persecution-type, but not in those with jealousy-type delusional disorder, compared with age- and sex-matched controls. This increased pHVA level was decreased eight weeks after successful haloperidol treatment. (3) The genotype frequency of the DRD2 gene Ser311Cys was significantly higher in patients with persecution-type delusional disorder (21%), compared with schizophrenic patients (6%) or controls (6%). (4) Patients homozygous for the DRD3 gene Ser9Ser had higher pretreatment levels of pHVA than those heterozygous for Ser9Gly. (v) A significant positive correlation was found between the polymorphic (TCAT)n repeat in the first intron of the TH gene and pretreatment levels of pHVA in delusional disorder. We suggest that delusional disorder, especially the persecution-type, includes a “dopamine psychosis,” and that polymorphism of the DRD2, DRD3 and/or TH gene is part of the genetic basis underlying the hyperdopaminergic state that produces paranoid symptoms. Further studies on a large sample size are required." @default.
- W2076759566 created "2016-06-24" @default.
- W2076759566 creator A5015820480 @default.
- W2076759566 creator A5034067343 @default.
- W2076759566 creator A5039852793 @default.
- W2076759566 creator A5049278001 @default.
- W2076759566 creator A5078276425 @default.
- W2076759566 creator A5085117512 @default.
- W2076759566 date "2002-06-01" @default.
- W2076759566 modified "2023-10-18" @default.
- W2076759566 title "Delusional Disorder Molecular Genetic Evidence for Dopamine Psychosis" @default.
- W2076759566 cites W1499894735 @default.
- W2076759566 cites W1592670756 @default.
- W2076759566 cites W1694864989 @default.
- W2076759566 cites W171492885 @default.
- W2076759566 cites W1720425867 @default.
- W2076759566 cites W1965904098 @default.
- W2076759566 cites W1966092598 @default.
- W2076759566 cites W1968837218 @default.
- W2076759566 cites W1970737542 @default.
- W2076759566 cites W1970814820 @default.
- W2076759566 cites W1974541129 @default.
- W2076759566 cites W1978663763 @default.
- W2076759566 cites W1980073528 @default.
- W2076759566 cites W1983138582 @default.
- W2076759566 cites W1992763235 @default.
- W2076759566 cites W1994538247 @default.
- W2076759566 cites W1996327177 @default.
- W2076759566 cites W1998170906 @default.
- W2076759566 cites W1998922007 @default.
- W2076759566 cites W1999992635 @default.
- W2076759566 cites W2001242871 @default.
- W2076759566 cites W2004821472 @default.
- W2076759566 cites W2005826854 @default.
- W2076759566 cites W2006109714 @default.
- W2076759566 cites W2012686841 @default.
- W2076759566 cites W2014883109 @default.
- W2076759566 cites W2020834359 @default.
- W2076759566 cites W2024143123 @default.
- W2076759566 cites W2038409107 @default.
- W2076759566 cites W2043301369 @default.
- W2076759566 cites W2043532470 @default.
- W2076759566 cites W2046836464 @default.
- W2076759566 cites W2053004491 @default.
- W2076759566 cites W2057862928 @default.
- W2076759566 cites W2058749620 @default.
- W2076759566 cites W2063505213 @default.
- W2076759566 cites W2065886257 @default.
- W2076759566 cites W2067267731 @default.
- W2076759566 cites W2070871049 @default.
- W2076759566 cites W2074831881 @default.
- W2076759566 cites W2091256944 @default.
- W2076759566 cites W2091705535 @default.
- W2076759566 cites W2092416470 @default.
- W2076759566 cites W2092947663 @default.
- W2076759566 cites W2093905130 @default.
- W2076759566 cites W2097798815 @default.
- W2076759566 cites W2100321683 @default.
- W2076759566 cites W2114200019 @default.
- W2076759566 cites W2115478354 @default.
- W2076759566 cites W2128273381 @default.
- W2076759566 cites W2146084622 @default.
- W2076759566 cites W2149605430 @default.
- W2076759566 cites W2150760506 @default.
- W2076759566 cites W2151331628 @default.
- W2076759566 cites W2157208800 @default.
- W2076759566 cites W227156116 @default.
- W2076759566 cites W2284323937 @default.
- W2076759566 cites W2409313038 @default.
- W2076759566 cites W80704538 @default.
- W2076759566 cites W2327177575 @default.
- W2076759566 doi "https://doi.org/10.1016/s0893-133x(01)00421-3" @default.
- W2076759566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12007750" @default.
- W2076759566 hasPublicationYear "2002" @default.
- W2076759566 type Work @default.
- W2076759566 sameAs 2076759566 @default.
- W2076759566 citedByCount "48" @default.
- W2076759566 countsByYear W20767595662012 @default.
- W2076759566 countsByYear W20767595662013 @default.
- W2076759566 countsByYear W20767595662014 @default.
- W2076759566 countsByYear W20767595662015 @default.
- W2076759566 countsByYear W20767595662016 @default.
- W2076759566 countsByYear W20767595662017 @default.
- W2076759566 countsByYear W20767595662018 @default.
- W2076759566 countsByYear W20767595662019 @default.
- W2076759566 countsByYear W20767595662020 @default.
- W2076759566 countsByYear W20767595662021 @default.
- W2076759566 countsByYear W20767595662022 @default.
- W2076759566 countsByYear W20767595662023 @default.
- W2076759566 crossrefType "journal-article" @default.
- W2076759566 hasAuthorship W2076759566A5015820480 @default.
- W2076759566 hasAuthorship W2076759566A5034067343 @default.
- W2076759566 hasAuthorship W2076759566A5039852793 @default.
- W2076759566 hasAuthorship W2076759566A5049278001 @default.
- W2076759566 hasAuthorship W2076759566A5078276425 @default.
- W2076759566 hasAuthorship W2076759566A5085117512 @default.
- W2076759566 hasBestOaLocation W20767595661 @default.
- W2076759566 hasConcept C118552586 @default.