Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076766472> ?p ?o ?g. }
- W2076766472 endingPage "759" @default.
- W2076766472 startingPage "747" @default.
- W2076766472 abstract "The action of visual experience on visual cortical circuits is maximal during a critical period of postnatal development. The long-term effects of this experience are likely mediated by signaling cascades regulating experience-dependent gene transcription. Developmental modifications of these pathways could explain the difference in plasticity between the young and adult cortex. We studied the pathways linking experience-dependent activation of ERK to CREB-mediated gene expression in vivo. In juvenile mice, visual stimulation that activates CREB-mediated gene transcription also induced ERK-dependent MSK and histone H3 phosphorylation and H3-H4 acetylation, an epigenetic mechanism of gene transcription activation. In adult animals, ERK and MSK were still inducible; however, visual stimulation induced weak CREB-mediated gene expression and H3-H4 posttranslational modifications. Stimulation of histone acetylation in adult animals by means of trichostatin promoted ocular dominance plasticity. Thus, differing, experience-dependent activations of signaling molecules might be at the basis of the differences in experience-dependent plasticity between juvenile and adult cortex." @default.
- W2076766472 created "2016-06-24" @default.
- W2076766472 creator A5001048485 @default.
- W2076766472 creator A5007734615 @default.
- W2076766472 creator A5016100084 @default.
- W2076766472 creator A5020266509 @default.
- W2076766472 creator A5043647281 @default.
- W2076766472 creator A5062282121 @default.
- W2076766472 creator A5068315002 @default.
- W2076766472 date "2007-03-01" @default.
- W2076766472 modified "2023-10-14" @default.
- W2076766472 title "Developmental Downregulation of Histone Posttranslational Modifications Regulates Visual Cortical Plasticity" @default.
- W2076766472 cites W1501677532 @default.
- W2076766472 cites W1523008448 @default.
- W2076766472 cites W1545480326 @default.
- W2076766472 cites W1550873430 @default.
- W2076766472 cites W1678289273 @default.
- W2076766472 cites W1822505628 @default.
- W2076766472 cites W1842266333 @default.
- W2076766472 cites W1929487673 @default.
- W2076766472 cites W1963806203 @default.
- W2076766472 cites W1967364632 @default.
- W2076766472 cites W1973704051 @default.
- W2076766472 cites W1975402449 @default.
- W2076766472 cites W1982845356 @default.
- W2076766472 cites W1986126224 @default.
- W2076766472 cites W1987584850 @default.
- W2076766472 cites W1988181440 @default.
- W2076766472 cites W1989407684 @default.
- W2076766472 cites W1992811119 @default.
- W2076766472 cites W1992857164 @default.
- W2076766472 cites W2001891260 @default.
- W2076766472 cites W2005488274 @default.
- W2076766472 cites W2006584412 @default.
- W2076766472 cites W2008201324 @default.
- W2076766472 cites W2010285972 @default.
- W2076766472 cites W2016243020 @default.
- W2076766472 cites W2019601077 @default.
- W2076766472 cites W2023307129 @default.
- W2076766472 cites W2036029991 @default.
- W2076766472 cites W2036396876 @default.
- W2076766472 cites W2037969635 @default.
- W2076766472 cites W2038166974 @default.
- W2076766472 cites W2038483965 @default.
- W2076766472 cites W2040149722 @default.
- W2076766472 cites W2041136510 @default.
- W2076766472 cites W2042439588 @default.
- W2076766472 cites W2046244011 @default.
- W2076766472 cites W2046314213 @default.
- W2076766472 cites W2046459630 @default.
- W2076766472 cites W2047961525 @default.
- W2076766472 cites W2053738369 @default.
- W2076766472 cites W2054017008 @default.
- W2076766472 cites W2059337036 @default.
- W2076766472 cites W2065104375 @default.
- W2076766472 cites W2066607735 @default.
- W2076766472 cites W2067180576 @default.
- W2076766472 cites W2068412840 @default.
- W2076766472 cites W2070840393 @default.
- W2076766472 cites W2071212911 @default.
- W2076766472 cites W2075907707 @default.
- W2076766472 cites W2081524299 @default.
- W2076766472 cites W2083624932 @default.
- W2076766472 cites W2085299836 @default.
- W2076766472 cites W2085719869 @default.
- W2076766472 cites W2086168922 @default.
- W2076766472 cites W2088359631 @default.
- W2076766472 cites W2088475496 @default.
- W2076766472 cites W2091187766 @default.
- W2076766472 cites W2100157657 @default.
- W2076766472 cites W2100712519 @default.
- W2076766472 cites W2104069712 @default.
- W2076766472 cites W2105312616 @default.
- W2076766472 cites W2105398870 @default.
- W2076766472 cites W2118101881 @default.
- W2076766472 cites W2128966898 @default.
- W2076766472 cites W2131162745 @default.
- W2076766472 cites W2138718238 @default.
- W2076766472 cites W2143060613 @default.
- W2076766472 cites W2143524000 @default.
- W2076766472 cites W2146070554 @default.
- W2076766472 cites W2149858533 @default.
- W2076766472 cites W2151249546 @default.
- W2076766472 cites W2155905053 @default.
- W2076766472 cites W2161608940 @default.
- W2076766472 cites W2167321220 @default.
- W2076766472 doi "https://doi.org/10.1016/j.neuron.2007.02.007" @default.
- W2076766472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17329213" @default.
- W2076766472 hasPublicationYear "2007" @default.
- W2076766472 type Work @default.
- W2076766472 sameAs 2076766472 @default.
- W2076766472 citedByCount "179" @default.
- W2076766472 countsByYear W20767664722012 @default.
- W2076766472 countsByYear W20767664722013 @default.
- W2076766472 countsByYear W20767664722014 @default.
- W2076766472 countsByYear W20767664722015 @default.
- W2076766472 countsByYear W20767664722016 @default.
- W2076766472 countsByYear W20767664722017 @default.