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• W2076775404 abstract "Functional imaging studies have revealed overactivity of the hippocampus in schizophrenic patients. Neuropathological data indicate that hyperactivity of excitatory hippocampal afferents and decreased hippocampal GABA transmission contribute to this overactivity. In rats, excitation of the ventral hippocampus, e.g. by NMDA, results in hyperactivity and disruption of sensorimotor gating measured as prepulse inhibition (PPI) of the acoustic startle response, behavioral effects related to psychotic symptoms in humans.The present study examined whether disinhibition of the ventral hippocampus by the GABA(A) antagonist picrotoxin would result in similar psychosis-related behavioral disturbances (hyperactivity, decreased PPI) as NMDA stimulation.Wistar rats received bilateral infusions of subconvulsive doses of picrotoxin (100 or 150 ng/0.5 microl per side) into the ventral hippocampus and were then immediately tested for open field locomotor activity or startle reactivity and PPI. Only the higher dose induced hyperactivity and decreased PPI. Both doses decreased acoustic startle reactivity to a similar extent. The decreased PPI appeared not to result from decreased startle reactivity, but was associated with a diminished potency of the prepulses to inhibit the startle reaction to the startle pulse, indicating a sensorimotor gating deficit. All effects were temporary, i.e. disappeared when the rats were tested 24 h after infusion.Decreased GABAergic inhibition in the ventral hippocampus of rats yielded psychosis-related behavioral effects, very similar to those induced by NMDA stimulation. Thus, a concurrence of decreased GABAergic inhibition and increased afferent excitation in the hippocampus of schizophrenic patients might contribute to psychotic symptoms." @default.
• W2076775404 created "2016-06-24" @default.
• W2076775404 creator A5035011673 @default.
• W2076775404 creator A5068249564 @default.
• W2076775404 creator A5090047687 @default.
• W2076775404 date "2001-06-22" @default.
• W2076775404 modified "2023-10-12" @default.
• W2076775404 title "Hyperactivity, decreased startle reactivity, and disrupted prepulse inhibition following disinhibition of the rat ventral hippocampus by the GABAA receptor antagonist picrotoxin" @default.
• W2076775404 cites W127445890 @default.
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• W2076775404 cites W1622949992 @default.
• W2076775404 cites W1757694062 @default.
• W2076775404 cites W1774425324 @default.
• W2076775404 cites W185504891 @default.
• W2076775404 cites W1964240411 @default.
• W2076775404 cites W1969957609 @default.
• W2076775404 cites W1974154075 @default.
• W2076775404 cites W1980077228 @default.
• W2076775404 cites W1985310141 @default.
• W2076775404 cites W1986859027 @default.
• W2076775404 cites W1987683289 @default.
• W2076775404 cites W1989314580 @default.
• W2076775404 cites W1993639998 @default.
• W2076775404 cites W1993706485 @default.
• W2076775404 cites W1996717195 @default.
• W2076775404 cites W2004305039 @default.
• W2076775404 cites W2008025672 @default.
• W2076775404 cites W2008553208 @default.
• W2076775404 cites W2008830394 @default.
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• W2076775404 cites W2022503841 @default.
• W2076775404 cites W2037121244 @default.
• W2076775404 cites W2037877714 @default.
• W2076775404 cites W2039290631 @default.
• W2076775404 cites W2039301402 @default.
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• W2076775404 doi "https://doi.org/10.1007/s002130100775" @default.
• W2076775404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11549225" @default.
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