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- W2076778051 abstract "NPY receptors are identified in calf frontal cortex and hippocampus membrane preparations by binding of N-[propionyl-3H] neuropeptide Y. Saturation and competition binding data with PYY, NPY-(18-36) and NPY itself fit with a single class of sites: for the radioligand KD = 1.4 +/- 0.5 nM, Bmax = 434 +/- 180 fmol/mg protein in frontal cortex, KD = 0.7 +/- 0.2 nM, Bmax = 267 +/- 50 fmol/mg protein in hippocampus. Competition curves of the Y1-subtype selective agonist [Leu31, Pro34]NPY are biphasic in both membrane preparations: high affinity sites (i.e. Y1-subtype) amount to 80% in frontal cortex and 23% in hippocampus. The remaining sites are of the Y2-subtype. Out of 23 Conus venom preparations, 17 inhibit the binding of [3H]NPY in both membrane preparations, but only two of them (from Conus aulicus and C. pennaceus) do so with high potency (IC50 < 5 micrograms protein/ml). Only one venom preparation (from C. mercator) had weak discriminatory properties (IC50Y2/IC50Y1 = 6). Venom from C. anemone increased the [3H]NPY binding 5-fold and with an IC50 of 15-18 micrograms protein/ml. This binding occurred to the venom itself and was unrelated to the NPY receptors since it was equally potent when displaced by [Leu31, Pro34]NPY, NPY-(18-36), PYY and NPY." @default.
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- W2076778051 date "1996-12-01" @default.
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- W2076778051 title "NEUROPEPTIDE Y RECEPTORS FROM CALF BRAIN: EFFECT OF CRUDE CONUS VENOM PREPARATIONS ON [ 3 H]NPY BINDING" @default.
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- W2076778051 doi "https://doi.org/10.1016/s0197-0186(96)00066-6" @default.
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