FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076784490> ?p ?o ?g. }

• W2076784490 endingPage "1181" @default.
• W2076784490 startingPage "1174" @default.
• W2076784490 abstract "In Brief Objective: The present study was designed to determine whether Fructus Ligustri Lucidi (FLL) ethanol extract can directly regulate vitamin D metabolism both in vivo and in vitro. Methods: Eleven-month-old, aged Sprague-Dawley sham-operated and ovariectomized (OVX) female rats were fed a normal-calcium (Ca) diet (0.6% Ca, 0.65% phosphorus) and received either FLL (700 mg/kg) or vehicle daily for 12 weeks. The in vitro effects of FLL on vitamin D metabolism were studied using primary cultures of the rat renal proximal tubules. mRNA and protein expressions of 25-hydroxyvitamin D-1α hydroxylase (1-OHase) and vitamin D receptor (VDR) in the kidney and proximal tubule were measured using real-time polymerase chain reaction and Western blotting, respectively. The concentrations of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) synthesized by renal 1-OHase were measured by a competitive enzyme immunoassay. Results: FLL treatment significantly increased serum 1,25(OH)2D3 levels in both sham (P < 0.01) and OVX (P < 0.05) rats. FLL increased renal 1-OHase and VDR protein and mRNA expressions in sham rats. Protein expression of renal 1-OHase, but not VDR, was also up-regulated in OVX rats during FLL treatment. 1-OHase mRNA and 1-OHase activity were increased by FLL treatment in primary cultures of renal proximal tubule cells. Conclusions: FLL could increase the circulating levels of 1,25(OH)2D3 in vivo in aged female rats by directly stimulating 1-OHase activity. Thus, it might be an ideal oral agent that can help to improve the ability to induce 1,25(OH)2D3 synthesis and Ca balance in postmenopausal women who are of high risk of developing osteoporosis. The present study demonstrates that Fructus Ligustri Lucidi ethanol extract can directly regulate vitamin D metabolism both in vivo and in vitro. Fructus Ligustri Lucidi might be an ideal oral agent for postmenopausal women to improve 1, 25(OH)2D3 biosynthesis and calcium balance." @default.
• W2076784490 created "2016-06-24" @default.
• W2076784490 creator A5003741511 @default.
• W2076784490 creator A5038900936 @default.
• W2076784490 creator A5060756283 @default.
• W2076784490 creator A5069815551 @default.
• W2076784490 creator A5086664284 @default.
• W2076784490 date "2010-11-01" @default.
• W2076784490 modified "2023-09-27" @default.
• W2076784490 title "Ethanol extract of Fructus Ligustri Lucidi increases circulating 1,25-dihydroxyvitamin D3 by inducing renal 25-hydroxyvitamin D-1α hydroxylase activity" @default.
• W2076784490 cites W1963762281 @default.
• W2076784490 cites W1967983436 @default.
• W2076784490 cites W1969385982 @default.
• W2076784490 cites W1980408188 @default.
• W2076784490 cites W1990796758 @default.
• W2076784490 cites W1992045999 @default.
• W2076784490 cites W1993862261 @default.
• W2076784490 cites W1994840697 @default.
• W2076784490 cites W2008826830 @default.
• W2076784490 cites W2012270105 @default.
• W2076784490 cites W2017650323 @default.
• W2076784490 cites W2047504600 @default.
• W2076784490 cites W2059193476 @default.
• W2076784490 cites W2060908599 @default.
• W2076784490 cites W2074559070 @default.
• W2076784490 cites W2107614626 @default.
• W2076784490 cites W2119057793 @default.
• W2076784490 cites W2133492406 @default.
• W2076784490 cites W2135062403 @default.
• W2076784490 cites W2136414742 @default.
• W2076784490 cites W2141090628 @default.
• W2076784490 cites W2146872402 @default.
• W2076784490 cites W2146956322 @default.
• W2076784490 cites W2147487489 @default.
• W2076784490 cites W2151354212 @default.
• W2076784490 cites W2168785688 @default.
• W2076784490 cites W2171137599 @default.
• W2076784490 cites W2197704460 @default.
• W2076784490 cites W4211046201 @default.
• W2076784490 doi "https://doi.org/10.1097/gme.0b013e3181e39a2b" @default.
• W2076784490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20711082" @default.
• W2076784490 hasPublicationYear "2010" @default.
• W2076784490 type Work @default.
• W2076784490 sameAs 2076784490 @default.
• W2076784490 citedByCount "22" @default.
• W2076784490 countsByYear W20767844902012 @default.
• W2076784490 countsByYear W20767844902013 @default.
• W2076784490 countsByYear W20767844902014 @default.
• W2076784490 countsByYear W20767844902015 @default.
• W2076784490 countsByYear W20767844902016 @default.
• W2076784490 countsByYear W20767844902017 @default.
• W2076784490 countsByYear W20767844902018 @default.
• W2076784490 countsByYear W20767844902019 @default.
• W2076784490 countsByYear W20767844902021 @default.
• W2076784490 crossrefType "journal-article" @default.
• W2076784490 hasAuthorship W2076784490A5003741511 @default.
• W2076784490 hasAuthorship W2076784490A5038900936 @default.
• W2076784490 hasAuthorship W2076784490A5060756283 @default.
• W2076784490 hasAuthorship W2076784490A5069815551 @default.
• W2076784490 hasAuthorship W2076784490A5086664284 @default.
• W2076784490 hasConcept C104317684 @default.
• W2076784490 hasConcept C124490489 @default.
• W2076784490 hasConcept C126322002 @default.
• W2076784490 hasConcept C134018914 @default.
• W2076784490 hasConcept C150903083 @default.
• W2076784490 hasConcept C179639408 @default.
• W2076784490 hasConcept C185592680 @default.
• W2076784490 hasConcept C207001950 @default.
• W2076784490 hasConcept C2777164284 @default.
• W2076784490 hasConcept C2780091579 @default.
• W2076784490 hasConcept C55493867 @default.
• W2076784490 hasConcept C71924100 @default.
• W2076784490 hasConcept C8264082 @default.
• W2076784490 hasConcept C85265743 @default.
• W2076784490 hasConcept C86803240 @default.
• W2076784490 hasConceptScore W2076784490C104317684 @default.
• W2076784490 hasConceptScore W2076784490C124490489 @default.
• W2076784490 hasConceptScore W2076784490C126322002 @default.
• W2076784490 hasConceptScore W2076784490C134018914 @default.
• W2076784490 hasConceptScore W2076784490C150903083 @default.
• W2076784490 hasConceptScore W2076784490C179639408 @default.
• W2076784490 hasConceptScore W2076784490C185592680 @default.
• W2076784490 hasConceptScore W2076784490C207001950 @default.
• W2076784490 hasConceptScore W2076784490C2777164284 @default.
• W2076784490 hasConceptScore W2076784490C2780091579 @default.
• W2076784490 hasConceptScore W2076784490C55493867 @default.
• W2076784490 hasConceptScore W2076784490C71924100 @default.
• W2076784490 hasConceptScore W2076784490C8264082 @default.
• W2076784490 hasConceptScore W2076784490C85265743 @default.
• W2076784490 hasConceptScore W2076784490C86803240 @default.
• W2076784490 hasIssue "6" @default.
• W2076784490 hasLocation W20767844901 @default.
• W2076784490 hasLocation W20767844902 @default.
• W2076784490 hasOpenAccess W2076784490 @default.
• W2076784490 hasPrimaryLocation W20767844901 @default.
• W2076784490 hasRelatedWork W1981503997 @default.
• W2076784490 hasRelatedWork W1995863458 @default.
• W2076784490 hasRelatedWork W2009754781 @default.

• next