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• W2076787553 abstract "The anti-viral type I interferon (IFN) response is initiated by the immediate induction of IFNβ, which is mainly controlled by the IFN-regulatory factor-3 (IRF-3). The signaling pathways mediating viral IRF-3 activation are only poorly defined. We show that the Rho GTPase Rac1 is activated upon virus infection and controls IRF-3 phosphorylation and activity. Inhibition of Rac1 leads to reduced IFNβ promoter activity and to enhanced virus production. As a downstream mediator of Rac signaling towards IRF-3, we have identified the kinase p21-activated kinase (PAK1). Furthermore, both Rac1 and PAK1 regulate the recently described IRF-3 activators, IκB kinase-ε and TANK-binding kinase-1, establishing a first canonical virus-induced IRF-3 activating pathway." @default.
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• W2076787553 date "2004-05-08" @default.
• W2076787553 modified "2023-09-24" @default.
• W2076787553 title "Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3" @default.
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• W2076787553 doi "https://doi.org/10.1016/j.febslet.2004.04.069" @default.
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