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- W2076787966 abstract "Background: Congenital Diaphragmatic Hernia (CDH) remains a significant cause of death in the newborn. With preoperative stabilization strategies and advances in neonatal critical care, survival in the term infant now approaches 70%.Although prematurity is the most significant risk factor for morbidity and mortality in most neonatal diseases, its impact on infants with CDH has been poorly described. We evaluated the outcomes of preterm (<37 weeks) infants with CDH compared to term infants from the Congenital Diaphragmatic Hernia Registry (CDHR). Methods: Prospectively collected data from liveborn infants with CDH was analyzed from the CDHR of 97 international institutions from January 1995 to July 2009. Preterm infants were defined as<37 weeks estimated gestational age at birth. Logistic regression and chi square analysis were performed. Results: 5,058 infants with CDH were identified. 36 infants were excluded due to incomplete data. There were 3,895 term infants (77.6%) with 1,127 preterm infants (22.4%). Overall survival was 68.7%. A higher percentage of term infants underwent ECMO and as well as a repair of CDH. Preterm infants had a greater percentage of chromosomal and major cardiac anomalies. Survival for infants who were repaired was high in both groups (Table). Survival decreased with decreasing gestational age (Graph). The odds ratio for death among preterm infants adjusted for ECMO, chromosomal, and major cardiac anomalies was 2.55 (95% CI: 2.19-2.97). View Large Image Figure Viewer" @default.
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- W2076787966 date "2010-02-01" @default.
- W2076787966 modified "2023-09-26" @default.
- W2076787966 title "Congenital Diaphragmatic Hernia in the Preterm Infant: A Report from the Congenital Diaphragmatic Hernia Study Group" @default.
- W2076787966 doi "https://doi.org/10.1016/j.jss.2009.11.086" @default.
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