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• W2076792470 abstract "Needle-free, cutaneous delivery of vaccines is particularly attractive not only due to high patient compliance and safety, but also because skin is a highly immuno-active organ containing large numbers of antigen presenting Langerhans' cells (LCs). The ability to efficiently deliver particulate vaccine carriers into the skin epidermis would allow direct targeting of antigens to LCs and generate strong systemic immunity. Here we show, through extensive histological and kinetic studies, that biodegradable poly(lactide-co-glycolide) particles can be efficiently delivered into the epidermis using optimized, permeation enhancing, topical formulations. Fluorescence microscopy of frozen sections and immuno-stained epidermal sheet preparations demonstrated that efficacy of particle penetration increased with decreasing particle size. Interestingly, different enhancers showed different kinetics of penetration although their peak efficacies were comparable. Furthermore, the delivered particles were associated with or were present inside epidermal LCs indicating successful targeting to antigen presenting cells. These results implicate that topical formulations of micro and nanoparticles could provide efficient needle-free cutaneous delivery of particle-based vaccine carriers." @default.
• W2076792470 created "2016-06-24" @default.
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• W2076792470 date "2004-01-01" @default.
• W2076792470 modified "2023-10-16" @default.
• W2076792470 title "Topical permeation enhancers efficiently deliver polymer micro and nanoparticles to epidermal Langerhans' cells" @default.
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• W2076792470 doi "https://doi.org/10.1016/s1773-2247(04)50047-3" @default.
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