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- W2076793940 abstract "Abstract A method has been established for measuring beta-adrenergic receptors in membranes prepared from rat mesenteric arteries. The beta-adrenergic antagonist 125 I-iodohydroxybenzylpindolol was used as ligand in direct binding experiments. In the presence of 10 −4 M phentolamine, 125 I-iodohydroxybenzylpindolol binding was saturable, stereospecific, rapid and reversible. The relative potencies of beta-adrenergic agonists in displacing 125 I-iodohydroxybenzylpindolol correlated with their relative potencies in stimulating adenylate cyclase activity in artery homogenates. This method was used to measure beta-receptors in mesenteric arteries of rats made hypertensive by deoxycorticosterone-salt treatment. Arteries from rats with established hypertension contained a reduced concentration of betaadrenergic receptors. This decrease was from 10.1 ± 1.5 (S.E.M.) to 7.0 ± 1.2 fmoles/mg protein. There was no change in affinity for 125 I-iodohydroxybenzylpindolol (0.10 ± 0.02n M )." @default.
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- W2076793940 date "1980-06-01" @default.
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- W2076793940 title "Reduced vascular beta-adrenergic receptors in deoxycorticosterone-salt hypertensive rats" @default.
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- W2076793940 doi "https://doi.org/10.1016/0006-2952(80)90595-x" @default.
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