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• W2076795241 abstract "The maintenance of fuel homeostasis is critically dependent on a constant and constantly adjusted supply of insulin from the endocrine pancreas. An output of insulin adequate to meet extrapancreatic insulin requirements is ensured by a series of nutritional, hormonal, neural, and ontogenic factors, which all participate in the control of insulin secretion (Malaisse 1972). Most of these factors have, in either an immediate or delayed fashion, direct effects upon pancreatic B cells located in the islets of Langerhans. B cells must both be equipped with a series of suitable sensor systems in order to identify each regulatory factor, and be suitably organized to integrate the information provided by each sensor system, in order eventually to respond with an adequate rate of hormonal release. This situation can be visualized as a multifactorial control of a single release process (Malaisse 1973). Among the factors conceivably involved in the immediate regulation of insulin release under physiological conditions, four major types can be identified. They are circulating nutrients, cholinergic neurotransmitters, adrenergic agents, and peptidergic hormones. The present contribution deals mainly with the mechanisms for the insulinotropic action of these four types of factors. A brief description of the overall functional organization of the B cell will, however, be presented first." @default.
• W2076795241 created "2016-06-24" @default.
• W2076795241 creator A5020829082 @default.
• W2076795241 date "1988-01-01" @default.
• W2076795241 modified "2023-09-25" @default.
• W2076795241 title "Stimulus-Secretion Coupling in the Pancreatic B Cell" @default.
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• W2076795241 doi "https://doi.org/10.1007/978-3-642-73495-3_8" @default.
• W2076795241 hasPublicationYear "1988" @default.
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