Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076804940> ?p ?o ?g. }
- W2076804940 endingPage "793" @default.
- W2076804940 startingPage "773" @default.
- W2076804940 abstract "Licorice, one of the oldest and most popular herbal medicines in the world, has been widely used in traditional Chinese medicine as a cough reliever, anti-inflammatory, anti-anabrosis, immunomodulatory, anti-platelet, antiviral (hepatitis) and detoxifying agent. Licorice was used as an example to show drug discovery from herbal drugs using systems approaches and polypharmacology.Herbal medicines are becoming more mainstream in clinical practice and show value in treating and preventing diseases. However, due to its extreme complexity both in chemical components and mechanisms of action, deep understanding of botanical drugs is still difficult. Thus, a comprehensive systems approach which could identify active ingredients and their targets in the crude drugs and more importantly, understand the biological basis for the pharmacological properties of herbal medicines is necessary.In this study, a novel systems pharmacology model that integrates oral bioavailability screening, drug-likeness evaluation, blood-brain barrier permeation, target identification and network analysis has been established to investigate the herbal medicines.The comprehensive systems approach effectively identified 73 bioactive components from licorice and 91 potential targets for this medicinal herb. These 91 targets are closely associated with a series of diseases of respiratory system, cardiovascular system, and gastrointestinal system, etc. These targets are further mapped to drug-target and drug-target-disease networks to elucidate the mechanism of this herbal medicine.This work provides a novel in silico strategy for investigation of the botanical drugs containing a huge number of components, which has been demonstrated by the well-studied licorice case. This attempt should be helpful for understanding definite mechanisms of action for herbal medicines and discovery of new drugs from plants." @default.
- W2076804940 created "2016-06-24" @default.
- W2076804940 creator A5006924966 @default.
- W2076804940 creator A5017811249 @default.
- W2076804940 creator A5049430606 @default.
- W2076804940 creator A5070666006 @default.
- W2076804940 creator A5085353674 @default.
- W2076804940 date "2013-04-01" @default.
- W2076804940 modified "2023-10-11" @default.
- W2076804940 title "Systems approaches and polypharmacology for drug discovery from herbal medicines: An example using licorice" @default.
- W2076804940 cites W1527819727 @default.
- W2076804940 cites W1544009106 @default.
- W2076804940 cites W1702435110 @default.
- W2076804940 cites W1863396779 @default.
- W2076804940 cites W1963843006 @default.
- W2076804940 cites W1964141930 @default.
- W2076804940 cites W1965938589 @default.
- W2076804940 cites W1968179062 @default.
- W2076804940 cites W1970428333 @default.
- W2076804940 cites W1970477038 @default.
- W2076804940 cites W1976054193 @default.
- W2076804940 cites W1983088368 @default.
- W2076804940 cites W1986240377 @default.
- W2076804940 cites W1991965285 @default.
- W2076804940 cites W1992592020 @default.
- W2076804940 cites W1992594876 @default.
- W2076804940 cites W1994283960 @default.
- W2076804940 cites W1997450720 @default.
- W2076804940 cites W1998086294 @default.
- W2076804940 cites W1999278785 @default.
- W2076804940 cites W2001245423 @default.
- W2076804940 cites W2005126850 @default.
- W2076804940 cites W2009646199 @default.
- W2076804940 cites W2011798977 @default.
- W2076804940 cites W2013097901 @default.
- W2076804940 cites W2015098698 @default.
- W2076804940 cites W2015112775 @default.
- W2076804940 cites W2016327030 @default.
- W2076804940 cites W2017226027 @default.
- W2076804940 cites W2018040437 @default.
- W2076804940 cites W2022584773 @default.
- W2076804940 cites W2024450363 @default.
- W2076804940 cites W2027706303 @default.
- W2076804940 cites W2028023433 @default.
- W2076804940 cites W2029944874 @default.
- W2076804940 cites W2032123459 @default.
- W2076804940 cites W2033591223 @default.
- W2076804940 cites W2034594119 @default.
- W2076804940 cites W2035255429 @default.
- W2076804940 cites W2035605859 @default.
- W2076804940 cites W2040715497 @default.
- W2076804940 cites W2040724811 @default.
- W2076804940 cites W2044002635 @default.
- W2076804940 cites W2047319932 @default.
- W2076804940 cites W2052833170 @default.
- W2076804940 cites W2052956067 @default.
- W2076804940 cites W2053162151 @default.
- W2076804940 cites W2057090386 @default.
- W2076804940 cites W2059190358 @default.
- W2076804940 cites W2059673054 @default.
- W2076804940 cites W2060171803 @default.
- W2076804940 cites W2060619840 @default.
- W2076804940 cites W2064165080 @default.
- W2076804940 cites W2064822275 @default.
- W2076804940 cites W2066370788 @default.
- W2076804940 cites W2070603512 @default.
- W2076804940 cites W2070835301 @default.
- W2076804940 cites W2071508654 @default.
- W2076804940 cites W2072244957 @default.
- W2076804940 cites W2072878891 @default.
- W2076804940 cites W2074101391 @default.
- W2076804940 cites W2075180047 @default.
- W2076804940 cites W2076908903 @default.
- W2076804940 cites W2085666647 @default.
- W2076804940 cites W2086005158 @default.
- W2076804940 cites W2086306676 @default.
- W2076804940 cites W2086647019 @default.
- W2076804940 cites W2087783979 @default.
- W2076804940 cites W2089564589 @default.
- W2076804940 cites W2094371612 @default.
- W2076804940 cites W2105668062 @default.
- W2076804940 cites W2108271602 @default.
- W2076804940 cites W2113551867 @default.
- W2076804940 cites W2113558571 @default.
- W2076804940 cites W2118857937 @default.
- W2076804940 cites W2120848073 @default.
- W2076804940 cites W2127575302 @default.
- W2076804940 cites W2130409253 @default.
- W2076804940 cites W2130790725 @default.
- W2076804940 cites W2132300815 @default.
- W2076804940 cites W2133071516 @default.
- W2076804940 cites W2133776184 @default.
- W2076804940 cites W2137747104 @default.
- W2076804940 cites W2138489985 @default.
- W2076804940 cites W2139516171 @default.
- W2076804940 cites W2148595196 @default.
- W2076804940 cites W2148846737 @default.
- W2076804940 cites W2157851934 @default.