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- W2076808506 endingPage "e1561" @default.
- W2076808506 startingPage "e1561" @default.
- W2076808506 abstract "Abstract Glutamine utilization promotes enhanced growth of cancer cells. We propose a new concept map of cancer metabolism in which mitochondrial NADH and NADPH, in the presence of a dysfunctional electron transfer chain, promote reductive carboxylation from glutamine. We also discuss why nicotinamide nucleotide transhydrogenase (NNT) is required in vivo for glutamine utilization by reductive carboxylation. Moreover, NADPH, generated by both the pentose phosphate pathway and the cancer-specific serine glycolytic diversion, appears to sustain glutamine utilization for amino-acid synthesis, lipid synthesis, and for ROS quenching. The fact that the supply of NAD + precursors reduces tumor aggressiveness suggests experimental approaches to clarify the role of the NADH-driven redox network in cancer." @default.
- W2076808506 created "2016-06-24" @default.
- W2076808506 creator A5026838544 @default.
- W2076808506 creator A5053427006 @default.
- W2076808506 date "2014-12-04" @default.
- W2076808506 modified "2023-10-17" @default.
- W2076808506 title "Redox control of glutamine utilization in cancer" @default.
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