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- W2076811894 abstract "are not known. A recent in vitro study7 showed that the marked prolongation of action potential duration in Purkinje fibers induced by erythromycin is not caused by activation of the “late sodium” current or by a-adrenoceptor stimulation. A potential blocking effect on the potassium currents involved in ventricular repolarization (inward rectifier, Ik; delayed rectifier, Ikl; transient outward, Ito) cannot be excluded as a possible mechanism. The association between spiramycin and QT interval prolongation must of course be confirmed prospectively in a larger population by recording the ECG before and during antibiotic therapy. However, extreme caution should be used in the choice of macrolide agents when antibiotic therapy is necessary in subjects with alterations of ventricular repolarization or in those with reduced cardiac electrical stability." @default.
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- W2076811894 date "1993-09-01" @default.
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- W2076811894 title "Role of a long-short sequence for initiation of atrioventricular reentry in Wolff-Parkinson-White syndrome" @default.
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