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- W2076814714 abstract "BackgroundThe Leloir-pathway genes encode the enzymatic machinery involved in the metabolism of galactose.ResultsIn the distantly related fungi Saccharomyces cerevisiae and Candida albicans, the genes encoding these enzymes are syntenically arranged, but the upstream regulatory regions are highly divergent. In S. cerevisiae, the Leloir-pathway genes are positively regulated by Gal4p acting through the UASG sequence CGG(N11)CCG. However, in C. albicans, the Gal4p and UASG combination is found to regulate genes unrelated to galactose metabolism. We identified a palindromic sequence that acts to control GAL10 expression in C. albicans in the presence of galactose. This palindrome is found upstream of other Leloir-pathway genes in C. albicans, and in the absence of other regulatory sequences, activation of expression through this sequence in the presence of galactose requires Cph1p, the homolog of the Ste12p transcription factor of S. cerevisiae.ConclusionsAlthough the cellular process of galactose induction of the Leloir pathway is conserved between the two organisms, the regulatory circuits achieving the cellular process are completely distinct." @default.
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- W2076814714 date "2007-06-01" @default.
- W2076814714 modified "2023-10-15" @default.
- W2076814714 title "Transcriptional Rewiring of Fungal Galactose-Metabolism Circuitry" @default.
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- W2076814714 doi "https://doi.org/10.1016/j.cub.2007.05.017" @default.
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