FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076815669> ?p ?o ?g. }

• W2076815669 endingPage "5537" @default.
• W2076815669 startingPage "5527" @default.
• W2076815669 abstract "Alzheimer's disease is characterized by two protein precipitates, extracellular amyloid plaques and intracellular neurofibrillary tangles (NFTs). The primary constituent of NFTs is a hyperphosphorylated form of the microtubule-binding protein tau. Hyperphosphorylation of tau on over 30 residues, primarily within proline-rich sequences, is associated with conformational changes whose nature is poorly defined. Peptides derived from the proline-rich region of tau (residues 174-242) were synthesized, and the conformations were analyzed for the nonphosphorylated and phosphorylated peptides. CD and NMR data indicate that phosphorylation of serine and threonine residues in proline-rich sequences induces a conformational change to a type II polyproline helix. The largest phosphorylation-dependent conformational changes observed by CD were for tau peptides incorporating residues 174-183 or residues 229-238. Phosphoserine and phosphothreonine residues exhibited ordered values of (3)J(alphaN) (3.1-6.2 Hz; mean = 4.7 Hz) compared to nonphosphorylated serine and threonine. Phosphorylation of a tau peptide consisting of tau residues 196-209 resulted in the disruption of a nascent alpha-helix. These results suggest that global reorganization of tau may occur upon hyperphosphorylation of proline-rich sequences in tau." @default.
• W2076815669 created "2016-06-24" @default.
• W2076815669 creator A5072255412 @default.
• W2076815669 creator A5072997251 @default.
• W2076815669 date "2006-04-05" @default.
• W2076815669 modified "2023-09-23" @default.
• W2076815669 title "Hyperphosphorylation of Tau Induces Local Polyproline II Helix" @default.
• W2076815669 cites W1600934558 @default.
• W2076815669 cites W1843397982 @default.
• W2076815669 cites W1966604955 @default.
• W2076815669 cites W1968428021 @default.
• W2076815669 cites W1971883721 @default.
• W2076815669 cites W1977257516 @default.
• W2076815669 cites W1983141756 @default.
• W2076815669 cites W1991863242 @default.
• W2076815669 cites W1999466646 @default.
• W2076815669 cites W2016170088 @default.
• W2076815669 cites W2017769481 @default.
• W2076815669 cites W2018733438 @default.
• W2076815669 cites W2021798993 @default.
• W2076815669 cites W2024873268 @default.
• W2076815669 cites W2036895290 @default.
• W2076815669 cites W2039321158 @default.
• W2076815669 cites W2040005341 @default.
• W2076815669 cites W2074808135 @default.
• W2076815669 cites W2079615523 @default.
• W2076815669 cites W2082148008 @default.
• W2076815669 cites W2083335494 @default.
• W2076815669 cites W2083753880 @default.
• W2076815669 cites W2088751510 @default.
• W2076815669 cites W2091893114 @default.
• W2076815669 cites W2106013076 @default.
• W2076815669 cites W2112352925 @default.
• W2076815669 cites W2137568584 @default.
• W2076815669 cites W2139936160 @default.
• W2076815669 cites W2160140178 @default.
• W2076815669 cites W2164136371 @default.
• W2076815669 cites W4252825050 @default.
• W2076815669 doi "https://doi.org/10.1021/bi052662c" @default.
• W2076815669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16634634" @default.
• W2076815669 hasPublicationYear "2006" @default.
• W2076815669 type Work @default.
• W2076815669 sameAs 2076815669 @default.
• W2076815669 citedByCount "77" @default.
• W2076815669 countsByYear W20768156692012 @default.
• W2076815669 countsByYear W20768156692013 @default.
• W2076815669 countsByYear W20768156692014 @default.
• W2076815669 countsByYear W20768156692015 @default.
• W2076815669 countsByYear W20768156692016 @default.
• W2076815669 countsByYear W20768156692017 @default.
• W2076815669 countsByYear W20768156692018 @default.
• W2076815669 countsByYear W20768156692019 @default.
• W2076815669 countsByYear W20768156692020 @default.
• W2076815669 countsByYear W20768156692021 @default.
• W2076815669 countsByYear W20768156692022 @default.
• W2076815669 countsByYear W20768156692023 @default.
• W2076815669 crossrefType "journal-article" @default.
• W2076815669 hasAuthorship W2076815669A5072255412 @default.
• W2076815669 hasAuthorship W2076815669A5072997251 @default.
• W2076815669 hasConcept C109300003 @default.
• W2076815669 hasConcept C11960822 @default.
• W2076815669 hasConcept C142724271 @default.
• W2076815669 hasConcept C185592680 @default.
• W2076815669 hasConcept C2775880066 @default.
• W2076815669 hasConcept C2776414213 @default.
• W2076815669 hasConcept C2778198054 @default.
• W2076815669 hasConcept C2778670691 @default.
• W2076815669 hasConcept C2779134260 @default.
• W2076815669 hasConcept C2779281246 @default.
• W2076815669 hasConcept C2779815552 @default.
• W2076815669 hasConcept C2780307904 @default.
• W2076815669 hasConcept C502032728 @default.
• W2076815669 hasConcept C515207424 @default.
• W2076815669 hasConcept C55493867 @default.
• W2076815669 hasConcept C71924100 @default.
• W2076815669 hasConceptScore W2076815669C109300003 @default.
• W2076815669 hasConceptScore W2076815669C11960822 @default.
• W2076815669 hasConceptScore W2076815669C142724271 @default.
• W2076815669 hasConceptScore W2076815669C185592680 @default.
• W2076815669 hasConceptScore W2076815669C2775880066 @default.
• W2076815669 hasConceptScore W2076815669C2776414213 @default.
• W2076815669 hasConceptScore W2076815669C2778198054 @default.
• W2076815669 hasConceptScore W2076815669C2778670691 @default.
• W2076815669 hasConceptScore W2076815669C2779134260 @default.
• W2076815669 hasConceptScore W2076815669C2779281246 @default.
• W2076815669 hasConceptScore W2076815669C2779815552 @default.
• W2076815669 hasConceptScore W2076815669C2780307904 @default.
• W2076815669 hasConceptScore W2076815669C502032728 @default.
• W2076815669 hasConceptScore W2076815669C515207424 @default.
• W2076815669 hasConceptScore W2076815669C55493867 @default.
• W2076815669 hasConceptScore W2076815669C71924100 @default.
• W2076815669 hasIssue "17" @default.
• W2076815669 hasLocation W20768156691 @default.
• W2076815669 hasLocation W20768156692 @default.
• W2076815669 hasOpenAccess W2076815669 @default.
• W2076815669 hasPrimaryLocation W20768156691 @default.
• W2076815669 hasRelatedWork W1966002653 @default.
• W2076815669 hasRelatedWork W1983465884 @default.

• next