Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076822143> ?p ?o ?g. }
- W2076822143 endingPage "e9783" @default.
- W2076822143 startingPage "e9783" @default.
- W2076822143 abstract "Background Diurnal variations in the incidence of events such as heart attack and stroke suggest a role for circadian rhythms in the etiology of cardiovascular disease. The aim of this study was to assess the influence of the suprachiasmatic nucleus (SCN) circadian clock on cardiovascular function. Methodology/Principal Findings Heart rate (HR), blood pressure (BP) and locomotor activity (LA) were measured in circadian mutant (Vipr2−/−) mice and wild type littermates, using implanted radio-telemetry devices. Sleep and wakefulness were studied in similar mice implanted with electroencephalograph (EEG) electrodes. There was less diurnal variation in the frequency and duration of bouts of rest/activity and sleep/wake in Vipr2−/− mice than in wild type (WT) and short “ultradian” episodes of arousal were more prominent, especially in constant conditions (DD). Activity was an important determinant of circadian variation in BP and HR in animals of both genotypes; altered timing of episodes of activity and rest (as well as sleep and wakefulness) across the day accounted for most of the difference between Vipr2−/− mice and WT. However, there was also a modest circadian rhythm of resting HR and BP that was independent of LA. Conclusions/Significance If appropriate methods of analysis are used that take into account sleep and locomotor activity level, mice are a good model for understanding the contribution of circadian timing to cardiovascular function. Future studies of the influence of sleep and wakefulness on cardiovascular physiology may help to explain accumulating evidence linking disrupted sleep with cardiovascular disease in man." @default.
- W2076822143 created "2016-06-24" @default.
- W2076822143 creator A5009172603 @default.
- W2076822143 creator A5020756430 @default.
- W2076822143 creator A5029224773 @default.
- W2076822143 creator A5041068322 @default.
- W2076822143 creator A5045773582 @default.
- W2076822143 creator A5048819660 @default.
- W2076822143 creator A5056007981 @default.
- W2076822143 creator A5064304317 @default.
- W2076822143 creator A5071922622 @default.
- W2076822143 creator A5084820716 @default.
- W2076822143 date "2010-03-22" @default.
- W2076822143 modified "2023-10-17" @default.
- W2076822143 title "Circadian Control of Mouse Heart Rate and Blood Pressure by the Suprachiasmatic Nuclei: Behavioral Effects Are More Significant than Direct Outputs" @default.
- W2076822143 cites W1521227715 @default.
- W2076822143 cites W1570118866 @default.
- W2076822143 cites W1735943819 @default.
- W2076822143 cites W1758200084 @default.
- W2076822143 cites W1808876722 @default.
- W2076822143 cites W1883140844 @default.
- W2076822143 cites W1965467644 @default.
- W2076822143 cites W1965555277 @default.
- W2076822143 cites W1966020412 @default.
- W2076822143 cites W1976234290 @default.
- W2076822143 cites W1996333896 @default.
- W2076822143 cites W1998349062 @default.
- W2076822143 cites W2013099460 @default.
- W2076822143 cites W2013900586 @default.
- W2076822143 cites W2017344107 @default.
- W2076822143 cites W2032793852 @default.
- W2076822143 cites W2042060172 @default.
- W2076822143 cites W2045137676 @default.
- W2076822143 cites W2056779910 @default.
- W2076822143 cites W2058650658 @default.
- W2076822143 cites W2063946784 @default.
- W2076822143 cites W2064947439 @default.
- W2076822143 cites W2079613722 @default.
- W2076822143 cites W2083696373 @default.
- W2076822143 cites W2087806624 @default.
- W2076822143 cites W2096670071 @default.
- W2076822143 cites W2096882849 @default.
- W2076822143 cites W2097456908 @default.
- W2076822143 cites W2098204603 @default.
- W2076822143 cites W2098498582 @default.
- W2076822143 cites W2108721999 @default.
- W2076822143 cites W2110792462 @default.
- W2076822143 cites W2117583882 @default.
- W2076822143 cites W2121847288 @default.
- W2076822143 cites W2122932666 @default.
- W2076822143 cites W2123162799 @default.
- W2076822143 cites W2123500448 @default.
- W2076822143 cites W2129971651 @default.
- W2076822143 cites W2134427402 @default.
- W2076822143 cites W2138330700 @default.
- W2076822143 cites W2139030135 @default.
- W2076822143 cites W2144506144 @default.
- W2076822143 cites W2148152432 @default.
- W2076822143 cites W2149295638 @default.
- W2076822143 cites W2155402067 @default.
- W2076822143 cites W2158817312 @default.
- W2076822143 cites W2159781994 @default.
- W2076822143 cites W2313938778 @default.
- W2076822143 cites W2438427005 @default.
- W2076822143 cites W3112761749 @default.
- W2076822143 cites W3217417991 @default.
- W2076822143 cites W2417257360 @default.
- W2076822143 cites W2482261143 @default.
- W2076822143 doi "https://doi.org/10.1371/journal.pone.0009783" @default.
- W2076822143 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2842429" @default.
- W2076822143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20339544" @default.
- W2076822143 hasPublicationYear "2010" @default.
- W2076822143 type Work @default.
- W2076822143 sameAs 2076822143 @default.
- W2076822143 citedByCount "66" @default.
- W2076822143 countsByYear W20768221432012 @default.
- W2076822143 countsByYear W20768221432013 @default.
- W2076822143 countsByYear W20768221432014 @default.
- W2076822143 countsByYear W20768221432015 @default.
- W2076822143 countsByYear W20768221432016 @default.
- W2076822143 countsByYear W20768221432017 @default.
- W2076822143 countsByYear W20768221432018 @default.
- W2076822143 countsByYear W20768221432019 @default.
- W2076822143 countsByYear W20768221432020 @default.
- W2076822143 countsByYear W20768221432021 @default.
- W2076822143 countsByYear W20768221432022 @default.
- W2076822143 countsByYear W20768221432023 @default.
- W2076822143 crossrefType "journal-article" @default.
- W2076822143 hasAuthorship W2076822143A5009172603 @default.
- W2076822143 hasAuthorship W2076822143A5020756430 @default.
- W2076822143 hasAuthorship W2076822143A5029224773 @default.
- W2076822143 hasAuthorship W2076822143A5041068322 @default.
- W2076822143 hasAuthorship W2076822143A5045773582 @default.
- W2076822143 hasAuthorship W2076822143A5048819660 @default.
- W2076822143 hasAuthorship W2076822143A5056007981 @default.
- W2076822143 hasAuthorship W2076822143A5064304317 @default.
- W2076822143 hasAuthorship W2076822143A5071922622 @default.
- W2076822143 hasAuthorship W2076822143A5084820716 @default.