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- W2076824032 abstract "Diverse pathophysiological processes (e.g. obesity, lifespan determination, addiction and male fertility) have been linked to the expression of specific isoforms of the adenylyl cyclases (AC1-AC10), the enzymes that generate cyclic AMP (cAMP). Our laboratory recently discovered a new mode of cAMP production, prominent in certain cell types, that is stimulated by any manoeuvre causing reduction of free [Ca(2+) ] within the lumen of the endoplasmic reticulum (ER) calcium store. Activation of this 'store-operated' pathway requires the ER Ca(2+) sensor, STIM1, but the identity of the enzymes responsible for cAMP production and how this process is regulated is unknown. Here, we used sensitive FRET-based sensors for cAMP in single cells combined with silencing and overexpression approaches to show that store-operated cAMP production occurred preferentially via the isoform AC3 in NCM460 colonic epithelial cells. Ca(2+) entry via the plasma membrane Ca(2+) channel, Orai1, suppressed cAMP production, independent of store refilling. These findings are an important first step towards defining the functional significance and to identify the protein composition of this novel Ca(2+) /cAMP crosstalk system." @default.
- W2076824032 created "2016-06-24" @default.
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- W2076824032 date "2012-10-29" @default.
- W2076824032 modified "2023-09-30" @default.
- W2076824032 title "Termination and activation of store-operated cyclic AMP production" @default.
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- W2076824032 doi "https://doi.org/10.1111/j.1582-4934.2012.01592.x" @default.
- W2076824032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3470754" @default.
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