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- W2076826596 abstract "We describe the actions and pharmacology of BRL 24924, a new gastric prokinetic agent, in conscious dogs. In Heidenhain pouch preparations, BRL 24924 (0.01–0.16 mg/kg i.v.) is a potent stimulant of interdigestive phasic motility (increases in intraluminal pressure), approximately 50 times more potent than metoclopramide. The stimulatory effect of BRL 24924 (0.025 mg/kg i.v.) was prevented by atropine (0.1 mg/kg s.c.). It was initially unaffected by hexamethonium (5 mg/kg i.v.), but hexamethonium prevented BRL 24924 from causing sustained stimulation of motility. The stimulatory activity of BRL 24924 (0.025 mg/kg i.v.) was unaffected by propranolol (3 mg/kg i.v.) or by phentolamine (1 mg/kg i.v.). The selective 5-hydroxytryptamine3 receptor antagonist granisetron (BRL 43694; 0.1 or 1.0 mg/kg i.v.) neither mimicked nor prevented the stimulatory actions of BRL 24924. In dogs with a gastric fistula, the gastric emptying of a liquid test meal was accelerated following BRL 24924 (0.1 mg/kg i.v.) but was unaffected by granisetron (0.1 and 1 mg/kg i.v.). We conclude that BRL 24924 is a potent, long-lasting, and effective stimulant of canine gastric motility, which accelerates gastric emptying. The pharmacology of BRL 24924 is discussed in terms of its relationship with myenteric 5-hydroxytryptamine receptors." @default.
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- W2076826596 date "2008-06-28" @default.
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- W2076826596 title "Stimulation of Canine Gastric Motility by BRL 24924, a New Gastric Prokinetic Agent" @default.
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- W2076826596 doi "https://doi.org/10.1111/j.1365-2982.1990.tb00036.x" @default.
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