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W2076827851 abstract "HomeCirculationVol. 122, No. 22Sudden Cardiac Death Prediction and Prevention Free AccessResearch ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessResearch ArticlePDF/EPUBSudden Cardiac Death Prediction and PreventionReport From a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop Glenn I. Fishman, Sumeet S. Chugh, John P. DiMarco, Christine M. Albert, Mark E. Anderson, Robert O. Bonow, Alfred E. Buxton, Peng-Sheng Chen, Mark Estes, Xavier Jouven, Raymond Kwong, David A. Lathrop, Alice M. Mascette, Jeanne M. Nerbonne, Brian O'Rourke, Richard L. Page, Dan M. Roden, David S. Rosenbaum, Nona Sotoodehnia, Natalia A. Trayanova and Zhi-Jie Zheng Glenn I. FishmanGlenn I. Fishman From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Sumeet S. ChughSumeet S. Chugh From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , John P. DiMarcoJohn P. DiMarco From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Christine M. AlbertChristine M. Albert From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Mark E. AndersonMark E. Anderson From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Robert O. BonowRobert O. Bonow From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Alfred E. BuxtonAlfred E. Buxton From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Peng-Sheng ChenPeng-Sheng Chen From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Mark EstesMark Estes From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Xavier JouvenXavier Jouven From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Raymond KwongRaymond Kwong From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , David A. LathropDavid A. Lathrop From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Alice M. MascetteAlice M. Mascette From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Jeanne M. NerbonneJeanne M. Nerbonne From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Brian O'RourkeBrian O'Rourke From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Richard L. PageRichard L. Page From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Dan M. RodenDan M. Roden From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , David S. RosenbaumDavid S. Rosenbaum From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Nona SotoodehniaNona Sotoodehnia From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author , Natalia A. TrayanovaNatalia A. Trayanova From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author and Zhi-Jie ZhengZhi-Jie Zheng From the New York University School of Medicine, New York, N.Y. (G.I.F.); Cedars-Sinai Medical Center, Los Angeles Calif. 90048 (S.S.C.); University of Virginia Health System, Charlottesville, Va. (J.P.D.); Brigham and Women's Hospital, Boston, Mass. (C.M.A.); University of Iowa, Iowa City, Iowa (M.E.A.); Northwestern University, Chicago, Ill. (R.O.B.); Rhode Island Hospital, Providence, R.I. (A.E.B.); Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind. (P.-S.C.); Tufts University School of Medicine, Boston, Mass. 02111 (M.E.); INSERM U970 University Paris Descartes, France (X.J.); The Brigham and Women's Hospital, Boston, Mass. (R.Y.K.); National Heart, Lung, and Blood Institute, Bethesda, Md. (A.M.M., D.A.L., Z.-J.Z); Washington University, St Louis, Mo. (J.M.N.); Johns Hopkins Hospital, Baltimore, Md. (B.O'R.); University of Wisconsin School of Medicine and Public Health, Madison, Wis. (R.L.P.); Vanderbilt University School of Medicine, Nashville, Tenn. (D.M.R.); MetroHealth Campus, Case Western Reserve University, Cleveland, O. (D.S.R.); University of Washington, Seattle, Wash. 98101 (N.S.); Johns Hopkins University, Baltimore, Md. (N.A.T.) Search for more papers by this author Originally published30 Nov 2010https://doi.org/10.1161/CIRCULATIONAHA.110.976092Circulation. 2010;122:2335–2348Despite the significant decline in coronary artery disease (CAD) mortality in the second half of the 20th century,1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 US lives annually.2 In North America and Europe the annual incidence of SCD ranges between 50 to 100 per 100 000 in the general population.3–6 Because of the absence of emergency medical response systems in most world regions, worldwide estimates are currently not available.7 However, even in the presence of advanced first responder systems for resuscitation of out-of-hospital cardiac arrest, the overall survival rate in a recent North American analysis was 4.6%.8 SCD can manifest as ventricular tachycardia (VT), ventricular fibrillation (VF), pulseless electric activity (PEA), or asystole. In a significant proportion of patients, SCD can present without warning or a recognized triggering mechanism. The mean age of those affected is in the mid 60s, and at least 40% of patients will suffer SCD before the age of 65.4 Consequently, enhancement of methodologies for prediction and prevention of SCD acquires a unique and critical importance for management of this significant public health issue.Prediction and prevention of SCD is an area of active investigation, but considerable challenges persist that limit the efficacy and cost-effectiveness of available methodologies.7,9,10 It was recognized early on that optimization of SCD risk stratification will require integration of multi-disciplinary efforts at the bench and bedside, with studies in the general population.11–13 This integration has yet to be effectively accomplished. There is also increasing awareness that more investigation needs to be directed toward identification of early predictors of SCD.14 Significant advancements have occurred for risk prediction in the inherited channelopathies15–17 and other inherited conditions that predispose to SCD, such as hypertrophic cardiomyopathy,18 but there is much to be accomplished in this regard for the more common complex phenotypes, such as SCD, among patients with CAD. Many cardiovascular treatments (eg, lipid lowering and antihypertensive agents, antiischemic interventions, and heart failure therapies) prevent or delay the progression of the cardiovascular diseases that are the most frequent cause of SCD. However, the current workshop focused specifically on risk prediction for arrhythmic death in cardiac populations rather than on the broader topics of prediction and prevention of cardiac diseases in general.Unfortunately, specific pharmacological therapies directed at the el" @default.
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W2076827851 date "2010-11-30" @default.
W2076827851 modified "2023-10-16" @default.
W2076827851 title "Sudden Cardiac Death Prediction and Prevention" @default.
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