Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076831885> ?p ?o ?g. }
- W2076831885 endingPage "107" @default.
- W2076831885 startingPage "102" @default.
- W2076831885 abstract "Background The intracellular mechanisms involved in the alpha-adrenoceptor- or hyperventilation-induced bronchoconstriction remain unknown. Because there is a direct relationship between phosphatidylinositol (PI) metabolism and airway smooth muscle contraction induced by muscarinic agonists, the authors examined the effects of carbachol (CCh), norepinephrine (NE), and hypocapnia on PI turnover in the airway smooth muscle. Methods Rat tracheal slices were incubated in Krebs-Henseleit solution containing LiCl and [3H]myo-inositol in the presence of NE, CCh, or neither. The PCO2 in the solution was 36 +/- 3 mmHg (normocapnia), 19 +/- 2 mmHg (moderate hypocapnia), or 5 +/- 2 mmHg (severe hypocapnia), respectively. [3H]inositol monophosphate (IP1) formed was counted with a liquid scintillation counter. Results Basal IP1 formed was greater at severe hypocapnia than at normocapnia. Norepinephrine- and CCh-induced IP1 formation were also greater at hypocapnia than at normocapnia. Conclusions These results indicate that CCh, NE, and hypocapnia stimulate PI turnover in the airway smooth muscle, which would cause bronchoconstriction, and hypocapnia also augments NE- and CCh-induced PI turnover, which could cause worsening of exercise-induced asthma and vagotonic asthma, respectively." @default.
- W2076831885 created "2016-06-24" @default.
- W2076831885 creator A5032388806 @default.
- W2076831885 creator A5034898005 @default.
- W2076831885 creator A5049935886 @default.
- W2076831885 creator A5051213912 @default.
- W2076831885 creator A5063048021 @default.
- W2076831885 creator A5086205374 @default.
- W2076831885 creator A5086483710 @default.
- W2076831885 date "1995-01-01" @default.
- W2076831885 modified "2023-10-16" @default.
- W2076831885 title "Carbachol, Norepinephrine, and Hypocapnia Stimulate Phosphatidylinositol Turnover in Rat Tracheal Slices " @default.
- W2076831885 cites W1583351160 @default.
- W2076831885 cites W174319616 @default.
- W2076831885 cites W1889236699 @default.
- W2076831885 cites W1973292223 @default.
- W2076831885 cites W1983362342 @default.
- W2076831885 cites W1984029095 @default.
- W2076831885 cites W1991675805 @default.
- W2076831885 cites W1994435273 @default.
- W2076831885 cites W1995506869 @default.
- W2076831885 cites W1998922551 @default.
- W2076831885 cites W2027154975 @default.
- W2076831885 cites W2036279035 @default.
- W2076831885 cites W2058177903 @default.
- W2076831885 cites W2072756389 @default.
- W2076831885 cites W2081217412 @default.
- W2076831885 cites W2089030113 @default.
- W2076831885 cites W2097665064 @default.
- W2076831885 cites W2114902417 @default.
- W2076831885 cites W2117590568 @default.
- W2076831885 cites W2128017977 @default.
- W2076831885 cites W2149541517 @default.
- W2076831885 cites W2154588586 @default.
- W2076831885 cites W2169562947 @default.
- W2076831885 cites W2210625968 @default.
- W2076831885 cites W2233026924 @default.
- W2076831885 cites W2238525991 @default.
- W2076831885 cites W2259004039 @default.
- W2076831885 cites W2259594190 @default.
- W2076831885 cites W2268464423 @default.
- W2076831885 cites W2337217417 @default.
- W2076831885 cites W2403468439 @default.
- W2076831885 cites W2414395264 @default.
- W2076831885 cites W2419551315 @default.
- W2076831885 cites W2430858762 @default.
- W2076831885 cites W35451826 @default.
- W2076831885 cites W73664722 @default.
- W2076831885 doi "https://doi.org/10.1097/00000542-199501000-00014" @default.
- W2076831885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7832291" @default.
- W2076831885 hasPublicationYear "1995" @default.
- W2076831885 type Work @default.
- W2076831885 sameAs 2076831885 @default.
- W2076831885 citedByCount "8" @default.
- W2076831885 countsByYear W20768318852013 @default.
- W2076831885 countsByYear W20768318852015 @default.
- W2076831885 crossrefType "journal-article" @default.
- W2076831885 hasAuthorship W2076831885A5032388806 @default.
- W2076831885 hasAuthorship W2076831885A5034898005 @default.
- W2076831885 hasAuthorship W2076831885A5049935886 @default.
- W2076831885 hasAuthorship W2076831885A5051213912 @default.
- W2076831885 hasAuthorship W2076831885A5063048021 @default.
- W2076831885 hasAuthorship W2076831885A5086205374 @default.
- W2076831885 hasAuthorship W2076831885A5086483710 @default.
- W2076831885 hasBestOaLocation W20768318851 @default.
- W2076831885 hasConcept C126322002 @default.
- W2076831885 hasConcept C134018914 @default.
- W2076831885 hasConcept C170493617 @default.
- W2076831885 hasConcept C184235292 @default.
- W2076831885 hasConcept C185592680 @default.
- W2076831885 hasConcept C2776042228 @default.
- W2076831885 hasConcept C2777037550 @default.
- W2076831885 hasConcept C2777449187 @default.
- W2076831885 hasConcept C2778866228 @default.
- W2076831885 hasConcept C2778988552 @default.
- W2076831885 hasConcept C2780610907 @default.
- W2076831885 hasConcept C2780769369 @default.
- W2076831885 hasConcept C2781382112 @default.
- W2076831885 hasConcept C33789571 @default.
- W2076831885 hasConcept C42219234 @default.
- W2076831885 hasConcept C534529494 @default.
- W2076831885 hasConcept C55493867 @default.
- W2076831885 hasConcept C71924100 @default.
- W2076831885 hasConceptScore W2076831885C126322002 @default.
- W2076831885 hasConceptScore W2076831885C134018914 @default.
- W2076831885 hasConceptScore W2076831885C170493617 @default.
- W2076831885 hasConceptScore W2076831885C184235292 @default.
- W2076831885 hasConceptScore W2076831885C185592680 @default.
- W2076831885 hasConceptScore W2076831885C2776042228 @default.
- W2076831885 hasConceptScore W2076831885C2777037550 @default.
- W2076831885 hasConceptScore W2076831885C2777449187 @default.
- W2076831885 hasConceptScore W2076831885C2778866228 @default.
- W2076831885 hasConceptScore W2076831885C2778988552 @default.
- W2076831885 hasConceptScore W2076831885C2780610907 @default.
- W2076831885 hasConceptScore W2076831885C2780769369 @default.
- W2076831885 hasConceptScore W2076831885C2781382112 @default.
- W2076831885 hasConceptScore W2076831885C33789571 @default.
- W2076831885 hasConceptScore W2076831885C42219234 @default.