Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076834739> ?p ?o ?g. }
- W2076834739 endingPage "76" @default.
- W2076834739 startingPage "69" @default.
- W2076834739 abstract "Numbers of in vitro spontaneous IgG, IgM and IgA plaque-forming cells (PFC) as assessed by a modification of the protein A haemolytic plaque assay were determined in the blood and synovial fluid of patients with seropositive rheumatoid arthritis (RA) and compared with those of control groups. The total numbers of PFC were significantly higher in the peripheral blood of patients with active seropositive RA than in that of normal controls. In addition, most B lymphocytes in the synovial fluid of patients with active seropositive RA were active immunoglobulin (Ig) producers, whereas synovial fluid lymphocytes from patients with inactive seropositive RA and seronegative arthritis were not. In general, IgA PFC were relatively high in blood, whereas IgG PFC dominated in the synovial fluid. IgM PFC appear to be relatively low in blood and synovial fluid. However, a relative increase of IgG PFC was noted in the peripheral blood of patients with active RA. To test for polyclonality of the increased Ig synthesis, we tested the sera of patients and controls for the presence of polyclonal antibodies against sheep erythrocytes (SRBC) and SRBC modified by fluorescein isothiocyanate (FITC) and trinitrophenyl (TNP). No differences were observed with SRBC and TNP-SRBC agglutinin titres between patients and controls, but patients with RA had higher titres of FITC-SRBC agglutinins than normal sera. This finding supports the concept of a polyclonal nature of antibody production in RA patients." @default.
- W2076834739 created "2016-06-24" @default.
- W2076834739 creator A5013847890 @default.
- W2076834739 creator A5019865629 @default.
- W2076834739 creator A5035576036 @default.
- W2076834739 date "1982-07-01" @default.
- W2076834739 modified "2023-10-01" @default.
- W2076834739 title "High Incidence of Spontaneous Ig-Producing Lymphocytes in Peripheral Blood and Synovial Fluid of Patients with Active Seropositive Rheumatoid Arthritis" @default.
- W2076834739 cites W1458091666 @default.
- W2076834739 cites W1501578255 @default.
- W2076834739 cites W1554817242 @default.
- W2076834739 cites W1598653265 @default.
- W2076834739 cites W1964532737 @default.
- W2076834739 cites W1964872478 @default.
- W2076834739 cites W1982227562 @default.
- W2076834739 cites W1984931023 @default.
- W2076834739 cites W1988920314 @default.
- W2076834739 cites W1990721102 @default.
- W2076834739 cites W1999214145 @default.
- W2076834739 cites W2007754417 @default.
- W2076834739 cites W2008575549 @default.
- W2076834739 cites W2021044670 @default.
- W2076834739 cites W2025003141 @default.
- W2076834739 cites W2030698538 @default.
- W2076834739 cites W2031411325 @default.
- W2076834739 cites W2038316808 @default.
- W2076834739 cites W2041155832 @default.
- W2076834739 cites W2045513702 @default.
- W2076834739 cites W2049021766 @default.
- W2076834739 cites W2055408664 @default.
- W2076834739 cites W2060248408 @default.
- W2076834739 cites W2064934015 @default.
- W2076834739 cites W2082536861 @default.
- W2076834739 cites W2087416264 @default.
- W2076834739 cites W2091306335 @default.
- W2076834739 cites W2105647668 @default.
- W2076834739 cites W2113894340 @default.
- W2076834739 cites W2116079002 @default.
- W2076834739 cites W2119822970 @default.
- W2076834739 cites W2127497673 @default.
- W2076834739 cites W2139918071 @default.
- W2076834739 cites W2156566720 @default.
- W2076834739 cites W2161988957 @default.
- W2076834739 cites W2165371901 @default.
- W2076834739 cites W2165449027 @default.
- W2076834739 cites W2334399547 @default.
- W2076834739 cites W2341969299 @default.
- W2076834739 doi "https://doi.org/10.1111/j.1365-3083.1982.tb00700.x" @default.
- W2076834739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6750772" @default.
- W2076834739 hasPublicationYear "1982" @default.
- W2076834739 type Work @default.
- W2076834739 sameAs 2076834739 @default.
- W2076834739 citedByCount "36" @default.
- W2076834739 crossrefType "journal-article" @default.
- W2076834739 hasAuthorship W2076834739A5013847890 @default.
- W2076834739 hasAuthorship W2076834739A5019865629 @default.
- W2076834739 hasAuthorship W2076834739A5035576036 @default.
- W2076834739 hasConcept C121332964 @default.
- W2076834739 hasConcept C137061746 @default.
- W2076834739 hasConcept C142724271 @default.
- W2076834739 hasConcept C159654299 @default.
- W2076834739 hasConcept C202751555 @default.
- W2076834739 hasConcept C203014093 @default.
- W2076834739 hasConcept C204787440 @default.
- W2076834739 hasConcept C2776164576 @default.
- W2076834739 hasConcept C2776232647 @default.
- W2076834739 hasConcept C2776268809 @default.
- W2076834739 hasConcept C2777019933 @default.
- W2076834739 hasConcept C2777077863 @default.
- W2076834739 hasConcept C2777575956 @default.
- W2076834739 hasConcept C55493867 @default.
- W2076834739 hasConcept C62520636 @default.
- W2076834739 hasConcept C71924100 @default.
- W2076834739 hasConcept C86803240 @default.
- W2076834739 hasConcept C91881484 @default.
- W2076834739 hasConcept C956191 @default.
- W2076834739 hasConceptScore W2076834739C121332964 @default.
- W2076834739 hasConceptScore W2076834739C137061746 @default.
- W2076834739 hasConceptScore W2076834739C142724271 @default.
- W2076834739 hasConceptScore W2076834739C159654299 @default.
- W2076834739 hasConceptScore W2076834739C202751555 @default.
- W2076834739 hasConceptScore W2076834739C203014093 @default.
- W2076834739 hasConceptScore W2076834739C204787440 @default.
- W2076834739 hasConceptScore W2076834739C2776164576 @default.
- W2076834739 hasConceptScore W2076834739C2776232647 @default.
- W2076834739 hasConceptScore W2076834739C2776268809 @default.
- W2076834739 hasConceptScore W2076834739C2777019933 @default.
- W2076834739 hasConceptScore W2076834739C2777077863 @default.
- W2076834739 hasConceptScore W2076834739C2777575956 @default.
- W2076834739 hasConceptScore W2076834739C55493867 @default.
- W2076834739 hasConceptScore W2076834739C62520636 @default.
- W2076834739 hasConceptScore W2076834739C71924100 @default.
- W2076834739 hasConceptScore W2076834739C86803240 @default.
- W2076834739 hasConceptScore W2076834739C91881484 @default.
- W2076834739 hasConceptScore W2076834739C956191 @default.
- W2076834739 hasIssue "1" @default.
- W2076834739 hasLocation W20768347391 @default.
- W2076834739 hasLocation W20768347392 @default.