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• W2076838302 startingPage "367" @default.
• W2076838302 abstract "The complex mechanisms that regulate the X chromosome lead to evolutionary and physiological variability in gene expression between species, the sexes, individuals, developmental stages, tissues and cell types. This Review discusses the causes and consequences of variability in X-linked gene expression. Genes on the mammalian X chromosome are present in one copy in males and two copies in females. The complex mechanisms that regulate the X chromosome lead to evolutionary and physiological variability in gene expression between species, the sexes, individuals, developmental stages, tissues and cell types. In early development, delayed and incomplete X chromosome inactivation (XCI) in some species causes variability in gene expression. Additional diversity stems from escape from XCI and from mosaicism or XCI skewing in females. This causes sex-specific differences that manifest as differential gene expression and associated phenotypes. Furthermore, the complexity and diversity of X dosage regulation affect the severity of diseases caused by X-linked mutations." @default.
• W2076838302 created "2016-06-24" @default.
• W2076838302 creator A5011158717 @default.
• W2076838302 creator A5012877749 @default.
• W2076838302 creator A5067240879 @default.
• W2076838302 creator A5087010534 @default.
• W2076838302 date "2014-04-15" @default.
• W2076838302 modified "2023-10-16" @default.
• W2076838302 title "X chromosome regulation: diverse patterns in development, tissues and disease" @default.
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