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- W2076845745 abstract "A model of chromatin-dependent DNA replication sequences was developed on the previously reported decondensation units hypothesis and its kinetic properties were examined by way of calculating various numerical indices using a Monte Carlo procedure. The model has much in common with the previous one but a fundamental difference is that the unit is assumed to consist of linearly arranged H-, D-, A- and S-zones each containing genes of different functional categories which are called H-, D-, A- and S-genes, respectively. The units are decondensed by the action of D-factors, i.e. decondensation factors, from H-zone to the end of S-zone and the genes in decondensed regions release signals to produce housekeeping enzymes, D-factors, A-factors and S-factors. These products are stored and at the same time degraded. A-factors activate replication origins in the decondensed regions and S-factors induce DNA synthesis at the activated origins. Replicated DNA is recondensed and gene activities are shut down in the recondensed chromatin. The factors are produced under the control of chromosome cycle and in turn affect chromosomes. Thus, dual control mechanism operates as Mazia and Prescott have argued. Biochemical and cytogenetic basis of this model was reviewed briefly and some results of simulation presented which include DNA synthesis rate vs. DNA content relationships. An outstanding characteristic of the model is the constancy of cellular state in A-subphase located in the late G1." @default.
- W2076845745 created "2016-06-24" @default.
- W2076845745 creator A5082324887 @default.
- W2076845745 date "1989-02-01" @default.
- W2076845745 modified "2023-09-27" @default.
- W2076845745 title "A model of chromatin-dependent DNA replication sequences based on the decondensation units hypothesis" @default.
- W2076845745 cites W130152560 @default.
- W2076845745 cites W131532494 @default.
- W2076845745 cites W1489910744 @default.
- W2076845745 cites W1490304590 @default.
- W2076845745 cites W1490525630 @default.
- W2076845745 cites W1506160043 @default.
- W2076845745 cites W1509950311 @default.
- W2076845745 cites W1511845394 @default.
- W2076845745 cites W1520417931 @default.
- W2076845745 cites W1521732896 @default.
- W2076845745 cites W1539637396 @default.
- W2076845745 cites W1568608608 @default.
- W2076845745 cites W1570879213 @default.
- W2076845745 cites W1576360850 @default.
- W2076845745 cites W1588250464 @default.
- W2076845745 cites W160380472 @default.
- W2076845745 cites W1882835806 @default.
- W2076845745 cites W1944717769 @default.
- W2076845745 cites W1947877958 @default.
- W2076845745 cites W1964208832 @default.
- W2076845745 cites W1965978281 @default.
- W2076845745 cites W1965996017 @default.
- W2076845745 cites W1966129713 @default.
- W2076845745 cites W1968971095 @default.
- W2076845745 cites W1971118226 @default.
- W2076845745 cites W1972750541 @default.
- W2076845745 cites W1974885902 @default.
- W2076845745 cites W1974970871 @default.
- W2076845745 cites W1976788086 @default.
- W2076845745 cites W1978125129 @default.
- W2076845745 cites W1978583145 @default.
- W2076845745 cites W1982609907 @default.
- W2076845745 cites W1983139423 @default.
- W2076845745 cites W1984069110 @default.
- W2076845745 cites W1986872292 @default.
- W2076845745 cites W1987266981 @default.
- W2076845745 cites W1987654699 @default.
- W2076845745 cites W1989668007 @default.
- W2076845745 cites W1990366861 @default.
- W2076845745 cites W1997200609 @default.
- W2076845745 cites W1997462031 @default.
- W2076845745 cites W1999052037 @default.
- W2076845745 cites W2000054385 @default.
- W2076845745 cites W2005290796 @default.
- W2076845745 cites W2008022646 @default.
- W2076845745 cites W2009439577 @default.
- W2076845745 cites W2015655705 @default.
- W2076845745 cites W2016381728 @default.
- W2076845745 cites W2020550202 @default.
- W2076845745 cites W2020605925 @default.
- W2076845745 cites W2021095589 @default.
- W2076845745 cites W2021253208 @default.
- W2076845745 cites W2021982857 @default.
- W2076845745 cites W2022635015 @default.
- W2076845745 cites W2023338777 @default.
- W2076845745 cites W2023505637 @default.
- W2076845745 cites W2026876686 @default.
- W2076845745 cites W2027174012 @default.
- W2076845745 cites W2027775087 @default.
- W2076845745 cites W2028435598 @default.
- W2076845745 cites W2031675138 @default.
- W2076845745 cites W2032984278 @default.
- W2076845745 cites W2033384829 @default.
- W2076845745 cites W2034137085 @default.
- W2076845745 cites W2034578723 @default.
- W2076845745 cites W2037503536 @default.
- W2076845745 cites W2038932806 @default.
- W2076845745 cites W2041309454 @default.
- W2076845745 cites W2044078376 @default.
- W2076845745 cites W2044433340 @default.
- W2076845745 cites W2053269818 @default.
- W2076845745 cites W2053374394 @default.
- W2076845745 cites W2053437486 @default.
- W2076845745 cites W2054389038 @default.
- W2076845745 cites W2055121745 @default.
- W2076845745 cites W2055330891 @default.
- W2076845745 cites W2055906707 @default.
- W2076845745 cites W2056041200 @default.
- W2076845745 cites W2057607865 @default.
- W2076845745 cites W2059783614 @default.
- W2076845745 cites W2063473003 @default.
- W2076845745 cites W2064090029 @default.
- W2076845745 cites W2065096999 @default.
- W2076845745 cites W2065343344 @default.
- W2076845745 cites W2066561422 @default.
- W2076845745 cites W2066697492 @default.
- W2076845745 cites W2068779520 @default.
- W2076845745 cites W2069576619 @default.
- W2076845745 cites W2071209347 @default.
- W2076845745 cites W2073386386 @default.
- W2076845745 cites W2073882445 @default.
- W2076845745 cites W2074563618 @default.