FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076848660> ?p ?o ?g. }

• W2076848660 endingPage "193" @default.
• W2076848660 startingPage "187" @default.
• W2076848660 abstract "The long-term survival of patients with stage III non-small cell lung cancer treated with a combination of chemotherapy and radiation is 10% to 20%. Survival could potentially be increased and toxicity limited if one could identify patients most likely to respond to a particular treatment regimen. This project prospectively evaluated a panel of potential immunohistochemical markers of chemoresistance in a population of patients with pathology-confirmed stage III non-small cell lung cancer in order to determine the prognostic value of each marker in relation to response to chemotherapy or survival.Immunohistochemical staining was performed on histologically positive mediastinal nodal specimens obtained from 59 patients (mean age, 62 years; range, 41 to 79 years) without evidence of distant metastatic disease treated with navelbine-based chemotherapy and external beam radiation therapy between 1996 and 2001. Included were markers for apoptosis (p53, bcl-2), drug efflux/degradation (MDR, GST-pi), growth factors (EGFr, Her2-neu), and mismatch repair (hMLH1, hMSH2). After chemotherapy, patients underwent radiologic evaluation for response measured by standard criteria.After a median 41 months of follow-up (range, 17 to 55 months), 43 patients had recurrent disease and 38 of these patients were dead of cancer (median cancer-free survival of 10 months and overall survival of 18 months). Patients who demonstrated a complete or partial response (n = 38) had a significantly improved survival (p = 0.002) compared with those with stable or progressive cancer (n = 21). Multivariable Cox step-wise regression analysis of marker expression associated overexpression of p53 and low expression of hMSH2 with poor treatment response and cancer death.These preliminary data suggest that marker expression may allow the separation of patients into low- and high-risk groups with respect to survival after combined navelbine-based chemotherapy and XRT. This could represent a novel method of selecting patients for a particular treatment regimen if these data are reproduced in a larger prospective trial." @default.
• W2076848660 created "2016-06-24" @default.
• W2076848660 creator A5001948668 @default.
• W2076848660 creator A5011590188 @default.
• W2076848660 creator A5016744168 @default.
• W2076848660 creator A5019987454 @default.
• W2076848660 creator A5048443428 @default.
• W2076848660 creator A5056277456 @default.
• W2076848660 creator A5060835997 @default.
• W2076848660 date "2003-07-01" @default.
• W2076848660 modified "2023-10-10" @default.
• W2076848660 title "Measurement of chemoresistance markers in patients with stage iii non–small cell lung cancer: a novel approach for patient selection" @default.
• W2076848660 cites W1982097971 @default.
• W2076848660 cites W1985210117 @default.
• W2076848660 cites W1999489789 @default.
• W2076848660 cites W2014038672 @default.
• W2076848660 cites W2019934908 @default.
• W2076848660 cites W2021716162 @default.
• W2076848660 cites W2061828598 @default.
• W2076848660 cites W2066178728 @default.
• W2076848660 cites W2068776651 @default.
• W2076848660 cites W2090709861 @default.
• W2076848660 cites W2129170806 @default.
• W2076848660 cites W2137075269 @default.
• W2076848660 cites W2147312210 @default.
• W2076848660 cites W2155176893 @default.
• W2076848660 cites W2362403869 @default.
• W2076848660 cites W2404355448 @default.
• W2076848660 cites W2428270240 @default.
• W2076848660 cites W336115799 @default.
• W2076848660 doi "https://doi.org/10.1016/s0003-4975(03)00131-0" @default.
• W2076848660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12842538" @default.
• W2076848660 hasPublicationYear "2003" @default.
• W2076848660 type Work @default.
• W2076848660 sameAs 2076848660 @default.
• W2076848660 citedByCount "48" @default.
• W2076848660 countsByYear W20768486602012 @default.
• W2076848660 countsByYear W20768486602014 @default.
• W2076848660 countsByYear W20768486602016 @default.
• W2076848660 countsByYear W20768486602018 @default.
• W2076848660 countsByYear W20768486602019 @default.
• W2076848660 crossrefType "journal-article" @default.
• W2076848660 hasAuthorship W2076848660A5001948668 @default.
• W2076848660 hasAuthorship W2076848660A5011590188 @default.
• W2076848660 hasAuthorship W2076848660A5016744168 @default.
• W2076848660 hasAuthorship W2076848660A5019987454 @default.
• W2076848660 hasAuthorship W2076848660A5048443428 @default.
• W2076848660 hasAuthorship W2076848660A5056277456 @default.
• W2076848660 hasAuthorship W2076848660A5060835997 @default.
• W2076848660 hasConcept C121608353 @default.
• W2076848660 hasConcept C126322002 @default.
• W2076848660 hasConcept C142724271 @default.
• W2076848660 hasConcept C143998085 @default.
• W2076848660 hasConcept C146357865 @default.
• W2076848660 hasConcept C151730666 @default.
• W2076848660 hasConcept C2776256026 @default.
• W2076848660 hasConcept C2776694085 @default.
• W2076848660 hasConcept C2778336483 @default.
• W2076848660 hasConcept C2781413609 @default.
• W2076848660 hasConcept C2908647359 @default.
• W2076848660 hasConcept C509974204 @default.
• W2076848660 hasConcept C71924100 @default.
• W2076848660 hasConcept C86803240 @default.
• W2076848660 hasConcept C90924648 @default.
• W2076848660 hasConcept C99454951 @default.
• W2076848660 hasConceptScore W2076848660C121608353 @default.
• W2076848660 hasConceptScore W2076848660C126322002 @default.
• W2076848660 hasConceptScore W2076848660C142724271 @default.
• W2076848660 hasConceptScore W2076848660C143998085 @default.
• W2076848660 hasConceptScore W2076848660C146357865 @default.
• W2076848660 hasConceptScore W2076848660C151730666 @default.
• W2076848660 hasConceptScore W2076848660C2776256026 @default.
• W2076848660 hasConceptScore W2076848660C2776694085 @default.
• W2076848660 hasConceptScore W2076848660C2778336483 @default.
• W2076848660 hasConceptScore W2076848660C2781413609 @default.
• W2076848660 hasConceptScore W2076848660C2908647359 @default.
• W2076848660 hasConceptScore W2076848660C509974204 @default.
• W2076848660 hasConceptScore W2076848660C71924100 @default.
• W2076848660 hasConceptScore W2076848660C86803240 @default.
• W2076848660 hasConceptScore W2076848660C90924648 @default.
• W2076848660 hasConceptScore W2076848660C99454951 @default.
• W2076848660 hasIssue "1" @default.
• W2076848660 hasLocation W20768486601 @default.
• W2076848660 hasLocation W20768486602 @default.
• W2076848660 hasOpenAccess W2076848660 @default.
• W2076848660 hasPrimaryLocation W20768486601 @default.
• W2076848660 hasRelatedWork W2063282481 @default.
• W2076848660 hasRelatedWork W2329386257 @default.
• W2076848660 hasRelatedWork W2380330452 @default.
• W2076848660 hasRelatedWork W2384274503 @default.
• W2076848660 hasRelatedWork W2384740383 @default.
• W2076848660 hasRelatedWork W2386504342 @default.
• W2076848660 hasRelatedWork W2410163895 @default.
• W2076848660 hasRelatedWork W3106263696 @default.
• W2076848660 hasRelatedWork W4243189022 @default.
• W2076848660 hasRelatedWork W1540236315 @default.
• W2076848660 hasVolume "76" @default.
• W2076848660 isParatext "false" @default.

• next