FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076848939> ?p ?o ?g. }

• W2076848939 endingPage "e104462" @default.
• W2076848939 startingPage "e104462" @default.
• W2076848939 abstract "We recently characterized DahlS.Z-Leprfa/Leprfa (DS/obese) rats, derived from a cross between Dahl salt-sensitive rats and Zucker rats, as a new animal model of metabolic syndrome (MetS). Although the phenotype of DS/obese rats is similar to that of humans with MetS, the pathophysiological and metabolic characteristics in each cell type remain to be clarified. Hence, the establishment of induced pluripotent stem cells (iPSCs) derived from MetS rats is essential for investigations of MetS in vitro. Reports of rat iPSCs (riPSCs), however, are few because of the difficulty of comparing to other rodents such as mouse. Recently, the advantage of using mesenchymal stromal cells (MSCs) as a cell source for generating iPSCs was described. We aimed to establish riPSCs from MSCs in adipose tissues of both DS/obese rats and their lean littermates, DahlS.Z-Lepr+/Lepr+ (DS/lean) rats using lentivirus vectors with only three factors Oct4, Klf4, and Sox2 without c-Myc. The morphology, gene expression profiles, and protein expression of established colonies showed embryonic stem cell (ESCs)-like properties, and the differentiation potential into cells from all three germ layers both in vitro and in vivo (teratomas). Both riPSCs became adipocytes after induction of adipogenesis by insulin, T3, and dexamethasone. Real-time PCR analysis also revealed that both riPSCs and the adipose tissue from DS/obese and DS/lean rats possess similar expression patterns of adipocyte differentiation-related genes. We succeeded in generating riPSCs effectively from MSCs of both DS/obese and DS/lean rats. These riPSCs may well serve as highly effective tools for the investigation of MetS pathophysiology in vitro." @default.
• W2076848939 created "2016-06-24" @default.
• W2076848939 creator A5026033071 @default.
• W2076848939 creator A5050216561 @default.
• W2076848939 creator A5067578519 @default.
• W2076848939 creator A5082051238 @default.
• W2076848939 creator A5086504566 @default.
• W2076848939 date "2014-08-11" @default.
• W2076848939 modified "2023-09-23" @default.
• W2076848939 title "Generation of Rat-Induced Pluripotent Stem Cells from a New Model of Metabolic Syndrome" @default.
• W2076848939 cites W1532262643 @default.
• W2076848939 cites W1971324809 @default.
• W2076848939 cites W1972434468 @default.
• W2076848939 cites W1980485390 @default.
• W2076848939 cites W1985300858 @default.
• W2076848939 cites W1999763921 @default.
• W2076848939 cites W2002786003 @default.
• W2076848939 cites W2013205740 @default.
• W2076848939 cites W2016335094 @default.
• W2076848939 cites W2019538882 @default.
• W2076848939 cites W2023168515 @default.
• W2076848939 cites W2045081995 @default.
• W2076848939 cites W2050740602 @default.
• W2076848939 cites W2081047787 @default.
• W2076848939 cites W2092837861 @default.
• W2076848939 cites W2095953924 @default.
• W2076848939 cites W2096216062 @default.
• W2076848939 cites W2100465572 @default.
• W2076848939 cites W2110623684 @default.
• W2076848939 cites W2125987139 @default.
• W2076848939 cites W2142920603 @default.
• W2076848939 cites W2160265415 @default.
• W2076848939 doi "https://doi.org/10.1371/journal.pone.0104462" @default.
• W2076848939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4128712" @default.
• W2076848939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25111735" @default.
• W2076848939 hasPublicationYear "2014" @default.
• W2076848939 type Work @default.
• W2076848939 sameAs 2076848939 @default.
• W2076848939 citedByCount "11" @default.
• W2076848939 countsByYear W20768489392014 @default.
• W2076848939 countsByYear W20768489392015 @default.
• W2076848939 countsByYear W20768489392016 @default.
• W2076848939 countsByYear W20768489392017 @default.
• W2076848939 countsByYear W20768489392018 @default.
• W2076848939 countsByYear W20768489392020 @default.
• W2076848939 countsByYear W20768489392021 @default.
• W2076848939 crossrefType "journal-article" @default.
• W2076848939 hasAuthorship W2076848939A5026033071 @default.
• W2076848939 hasAuthorship W2076848939A5050216561 @default.
• W2076848939 hasAuthorship W2076848939A5067578519 @default.
• W2076848939 hasAuthorship W2076848939A5082051238 @default.
• W2076848939 hasAuthorship W2076848939A5086504566 @default.
• W2076848939 hasBestOaLocation W20768489391 @default.
• W2076848939 hasConcept C104317684 @default.
• W2076848939 hasConcept C107459253 @default.
• W2076848939 hasConcept C122927707 @default.
• W2076848939 hasConcept C126322002 @default.
• W2076848939 hasConcept C134018914 @default.
• W2076848939 hasConcept C145103041 @default.
• W2076848939 hasConcept C148738053 @default.
• W2076848939 hasConcept C171089720 @default.
• W2076848939 hasConcept C198826908 @default.
• W2076848939 hasConcept C2776175234 @default.
• W2076848939 hasConcept C2777933648 @default.
• W2076848939 hasConcept C2778265714 @default.
• W2076848939 hasConcept C28328180 @default.
• W2076848939 hasConcept C54355233 @default.
• W2076848939 hasConcept C71924100 @default.
• W2076848939 hasConcept C86803240 @default.
• W2076848939 hasConcept C95444343 @default.
• W2076848939 hasConceptScore W2076848939C104317684 @default.
• W2076848939 hasConceptScore W2076848939C107459253 @default.
• W2076848939 hasConceptScore W2076848939C122927707 @default.
• W2076848939 hasConceptScore W2076848939C126322002 @default.
• W2076848939 hasConceptScore W2076848939C134018914 @default.
• W2076848939 hasConceptScore W2076848939C145103041 @default.
• W2076848939 hasConceptScore W2076848939C148738053 @default.
• W2076848939 hasConceptScore W2076848939C171089720 @default.
• W2076848939 hasConceptScore W2076848939C198826908 @default.
• W2076848939 hasConceptScore W2076848939C2776175234 @default.
• W2076848939 hasConceptScore W2076848939C2777933648 @default.
• W2076848939 hasConceptScore W2076848939C2778265714 @default.
• W2076848939 hasConceptScore W2076848939C28328180 @default.
• W2076848939 hasConceptScore W2076848939C54355233 @default.
• W2076848939 hasConceptScore W2076848939C71924100 @default.
• W2076848939 hasConceptScore W2076848939C86803240 @default.
• W2076848939 hasConceptScore W2076848939C95444343 @default.
• W2076848939 hasIssue "8" @default.
• W2076848939 hasLocation W20768489391 @default.
• W2076848939 hasLocation W20768489392 @default.
• W2076848939 hasLocation W20768489393 @default.
• W2076848939 hasLocation W20768489394 @default.
• W2076848939 hasOpenAccess W2076848939 @default.
• W2076848939 hasPrimaryLocation W20768489391 @default.
• W2076848939 hasRelatedWork W1544608456 @default.
• W2076848939 hasRelatedWork W1978560791 @default.
• W2076848939 hasRelatedWork W1979647427 @default.
• W2076848939 hasRelatedWork W1989361659 @default.

• next