Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076858416> ?p ?o ?g. }
- W2076858416 endingPage "346" @default.
- W2076858416 startingPage "341" @default.
- W2076858416 abstract "Hydroxylation of phenylalanine to tyrosine is the first and rate-limiting step in phenylalanine catabolism. Currently, there are data on the rate of phenylalanine hydroxylation in infants and adults but not in healthy children. Thus, the aim of the study reported here was to measure the rate of phenylalanine hydroxylation and oxidation in healthy school-aged children both when receiving diets with and without tyrosine. In addition, hydroxylation rates calculated from the isotopic enrichments of amino acids in plasma and in very LDL apoB-100 were compared. Eight healthy 6- to 10-y-old children were studied while receiving a control and again while receiving a tyrosine-free diet. Phenylalanine flux, hydroxylation, and oxidation were determined by a standard tracer protocol using oral administration of ¹³C-phenylalanine and ²H₂-tyrosine for 6 h. Phenylalanine hydroxylation rate of children fed a diet devoid of tyrosine was greater than that of children fed a diet containing tyrosine (40.25 ± 5.48 versus 29.55 ± 5.35 μmol · kg⁻¹ · h⁻¹; p < 0.01). Phenylalanine oxidation was not different from phenylalanine hydroxylation regardless of dietary tyrosine intake, suggesting that phenylalanine converted to tyrosine was mainly oxidized. In conclusion, healthy children are capable of converting phenylalanine to tyrosine, but the need for tyrosine cannot be met by providing extra phenylalanine." @default.
- W2076858416 created "2016-06-24" @default.
- W2076858416 creator A5008350505 @default.
- W2076858416 creator A5034709923 @default.
- W2076858416 creator A5067294454 @default.
- W2076858416 creator A5068674673 @default.
- W2076858416 date "2011-04-01" @default.
- W2076858416 modified "2023-09-26" @default.
- W2076858416 title "Rate of Phenylalanine Hydroxylation in Healthy School-Aged Children" @default.
- W2076858416 cites W1763610774 @default.
- W2076858416 cites W1861803788 @default.
- W2076858416 cites W1877788237 @default.
- W2076858416 cites W1885667592 @default.
- W2076858416 cites W1909375919 @default.
- W2076858416 cites W1938797702 @default.
- W2076858416 cites W1953270400 @default.
- W2076858416 cites W1974680686 @default.
- W2076858416 cites W1988024297 @default.
- W2076858416 cites W1990454697 @default.
- W2076858416 cites W2003304726 @default.
- W2076858416 cites W2018021476 @default.
- W2076858416 cites W2036694350 @default.
- W2076858416 cites W2058022794 @default.
- W2076858416 cites W2058272767 @default.
- W2076858416 cites W2066530401 @default.
- W2076858416 cites W2077537289 @default.
- W2076858416 cites W2097202188 @default.
- W2076858416 cites W2110570972 @default.
- W2076858416 cites W2112518793 @default.
- W2076858416 cites W2129359729 @default.
- W2076858416 cites W2134790044 @default.
- W2076858416 cites W2146536175 @default.
- W2076858416 cites W2150855617 @default.
- W2076858416 cites W2151265788 @default.
- W2076858416 cites W2162018731 @default.
- W2076858416 cites W2162724482 @default.
- W2076858416 cites W2166152549 @default.
- W2076858416 cites W2168113735 @default.
- W2076858416 cites W2242743872 @default.
- W2076858416 cites W2410427015 @default.
- W2076858416 cites W2410579477 @default.
- W2076858416 cites W2570497040 @default.
- W2076858416 cites W83718076 @default.
- W2076858416 doi "https://doi.org/10.1203/pdr.0b013e31820bbdcd" @default.
- W2076858416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21178823" @default.
- W2076858416 hasPublicationYear "2011" @default.
- W2076858416 type Work @default.
- W2076858416 sameAs 2076858416 @default.
- W2076858416 citedByCount "2" @default.
- W2076858416 countsByYear W20768584162014 @default.
- W2076858416 countsByYear W20768584162019 @default.
- W2076858416 crossrefType "journal-article" @default.
- W2076858416 hasAuthorship W2076858416A5008350505 @default.
- W2076858416 hasAuthorship W2076858416A5034709923 @default.
- W2076858416 hasAuthorship W2076858416A5067294454 @default.
- W2076858416 hasAuthorship W2076858416A5068674673 @default.
- W2076858416 hasBestOaLocation W20768584161 @default.
- W2076858416 hasConcept C126322002 @default.
- W2076858416 hasConcept C134018914 @default.
- W2076858416 hasConcept C181199279 @default.
- W2076858416 hasConcept C185592680 @default.
- W2076858416 hasConcept C207009774 @default.
- W2076858416 hasConcept C2776165026 @default.
- W2076858416 hasConcept C2777431362 @default.
- W2076858416 hasConcept C2781109383 @default.
- W2076858416 hasConcept C515207424 @default.
- W2076858416 hasConcept C55493867 @default.
- W2076858416 hasConcept C71924100 @default.
- W2076858416 hasConceptScore W2076858416C126322002 @default.
- W2076858416 hasConceptScore W2076858416C134018914 @default.
- W2076858416 hasConceptScore W2076858416C181199279 @default.
- W2076858416 hasConceptScore W2076858416C185592680 @default.
- W2076858416 hasConceptScore W2076858416C207009774 @default.
- W2076858416 hasConceptScore W2076858416C2776165026 @default.
- W2076858416 hasConceptScore W2076858416C2777431362 @default.
- W2076858416 hasConceptScore W2076858416C2781109383 @default.
- W2076858416 hasConceptScore W2076858416C515207424 @default.
- W2076858416 hasConceptScore W2076858416C55493867 @default.
- W2076858416 hasConceptScore W2076858416C71924100 @default.
- W2076858416 hasIssue "4" @default.
- W2076858416 hasLocation W20768584161 @default.
- W2076858416 hasLocation W20768584162 @default.
- W2076858416 hasOpenAccess W2076858416 @default.
- W2076858416 hasPrimaryLocation W20768584161 @default.
- W2076858416 hasRelatedWork W1981144665 @default.
- W2076858416 hasRelatedWork W2008355091 @default.
- W2076858416 hasRelatedWork W2054293840 @default.
- W2076858416 hasRelatedWork W2059353739 @default.
- W2076858416 hasRelatedWork W2066530401 @default.
- W2076858416 hasRelatedWork W2099121494 @default.
- W2076858416 hasRelatedWork W2155222141 @default.
- W2076858416 hasRelatedWork W2163959508 @default.
- W2076858416 hasRelatedWork W2321018560 @default.
- W2076858416 hasRelatedWork W2329217933 @default.
- W2076858416 hasVolume "69" @default.
- W2076858416 isParatext "false" @default.
- W2076858416 isRetracted "false" @default.
- W2076858416 magId "2076858416" @default.