Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076895720> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2076895720 endingPage "68" @default.
- W2076895720 startingPage "63" @default.
- W2076895720 abstract "Six metals and/or their compounds have been recognized as carcinogens: arsenic, beryllium, cadmium, chromium, cobalt and nickel. With the exception of arsenic, the main rote of exposure is inhalation and the main target organ is the lung. Arsenic is exceptional because it also produces tumors of skin and lung after oral uptake. With the exception of hexavalent chromium, carcinogenic metals are weak mutagens, if at all, and their mechanisms of carcinogenicity are still far from clear. A general feature of arsenic, cadmium, cobalt and nickel is their property to enhance the mutagenicity and carcinogenicity of directly acting genotoxic agents. These properties can be interpreted in terms of the ability of these metals to inhibit the repair of damaged DNA. However, because carcinogenic metals cause tumor development in experimental animals even under exclusion of further carcinogens, other mechanisms have to be envisaged, too. Evidence will be discussed that carcinogenic metal compounds alter patterns of gene expression leading to stimulated cell proliferation, either by activation of early genes (proto-oncogenes) or by interference with genes downregulating cell growth. Special reference will be devoted to the effects of cadmium and arsenic on gene expression, which have been studied extensively. Possible implications for occupational safety and health will be discussed." @default.
- W2076895720 created "2016-06-24" @default.
- W2076895720 creator A5087658581 @default.
- W2076895720 date "2002-02-01" @default.
- W2076895720 modified "2023-10-15" @default.
- W2076895720 title "Effects of carcinogenic metals on gene expression" @default.
- W2076895720 cites W1552681886 @default.
- W2076895720 cites W1912376315 @default.
- W2076895720 cites W1972952746 @default.
- W2076895720 cites W1974452557 @default.
- W2076895720 cites W1982800721 @default.
- W2076895720 cites W1992446415 @default.
- W2076895720 cites W1993815480 @default.
- W2076895720 cites W2004199930 @default.
- W2076895720 cites W2010747467 @default.
- W2076895720 cites W2037067089 @default.
- W2076895720 cites W2042614655 @default.
- W2076895720 cites W2044781471 @default.
- W2076895720 cites W2065763518 @default.
- W2076895720 cites W2067084274 @default.
- W2076895720 cites W2068449654 @default.
- W2076895720 cites W2073655872 @default.
- W2076895720 cites W2077076178 @default.
- W2076895720 cites W2086024398 @default.
- W2076895720 cites W2106969589 @default.
- W2076895720 cites W2112343685 @default.
- W2076895720 doi "https://doi.org/10.1016/s0378-4274(01)00484-2" @default.
- W2076895720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12052642" @default.
- W2076895720 hasPublicationYear "2002" @default.
- W2076895720 type Work @default.
- W2076895720 sameAs 2076895720 @default.
- W2076895720 citedByCount "129" @default.
- W2076895720 countsByYear W20768957202012 @default.
- W2076895720 countsByYear W20768957202013 @default.
- W2076895720 countsByYear W20768957202014 @default.
- W2076895720 countsByYear W20768957202015 @default.
- W2076895720 countsByYear W20768957202016 @default.
- W2076895720 countsByYear W20768957202017 @default.
- W2076895720 countsByYear W20768957202018 @default.
- W2076895720 countsByYear W20768957202019 @default.
- W2076895720 countsByYear W20768957202020 @default.
- W2076895720 countsByYear W20768957202021 @default.
- W2076895720 countsByYear W20768957202022 @default.
- W2076895720 countsByYear W20768957202023 @default.
- W2076895720 crossrefType "journal-article" @default.
- W2076895720 hasAuthorship W2076895720A5087658581 @default.
- W2076895720 hasConcept C114246631 @default.
- W2076895720 hasConcept C178790620 @default.
- W2076895720 hasConcept C185592680 @default.
- W2076895720 hasConcept C502230775 @default.
- W2076895720 hasConcept C502942594 @default.
- W2076895720 hasConcept C544657597 @default.
- W2076895720 hasConcept C55493867 @default.
- W2076895720 hasConcept C86803240 @default.
- W2076895720 hasConceptScore W2076895720C114246631 @default.
- W2076895720 hasConceptScore W2076895720C178790620 @default.
- W2076895720 hasConceptScore W2076895720C185592680 @default.
- W2076895720 hasConceptScore W2076895720C502230775 @default.
- W2076895720 hasConceptScore W2076895720C502942594 @default.
- W2076895720 hasConceptScore W2076895720C544657597 @default.
- W2076895720 hasConceptScore W2076895720C55493867 @default.
- W2076895720 hasConceptScore W2076895720C86803240 @default.
- W2076895720 hasIssue "1-3" @default.
- W2076895720 hasLocation W20768957201 @default.
- W2076895720 hasLocation W20768957202 @default.
- W2076895720 hasOpenAccess W2076895720 @default.
- W2076895720 hasPrimaryLocation W20768957201 @default.
- W2076895720 hasRelatedWork W1531601525 @default.
- W2076895720 hasRelatedWork W1974648164 @default.
- W2076895720 hasRelatedWork W2017460424 @default.
- W2076895720 hasRelatedWork W2606230654 @default.
- W2076895720 hasRelatedWork W2607424097 @default.
- W2076895720 hasRelatedWork W2748952813 @default.
- W2076895720 hasRelatedWork W2899084033 @default.
- W2076895720 hasRelatedWork W2948807893 @default.
- W2076895720 hasRelatedWork W4387497383 @default.
- W2076895720 hasRelatedWork W2778153218 @default.
- W2076895720 hasVolume "127" @default.
- W2076895720 isParatext "false" @default.
- W2076895720 isRetracted "false" @default.
- W2076895720 magId "2076895720" @default.
- W2076895720 workType "article" @default.