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• W2076899615 abstract "Gentamicin resistance has emerged since 1971 among gram-negative bacilli isolated at the University of Virginia Hospital. Of 9,169 gram-negative bacilli isolated in 1971, 0.8 per cent were resistant to gentamicin by disc sensitivity testing. Of 7,817 isolates in 1975, 7.7 per cent were resistant. Approximately 20 per cent of the Klebsiellae had a minimum inhibitory concentration (MIC) ≥ 16 μg/ml of gentamicin. Since 1974, gentamicin-resistant gram-negative bacilli have accounted for 20 per cent of nosocomial bacteremias. In 1974–1975, 34 episodes of gentamicin-resistant bacteremia occurred. All were in patients with severe underlying diseases who had been hospitalized for longer than four days; 24 (71 per cent) occurred in patients in intensive care units. The organisms isolated were Klebsiella pneumoniae (12 cases), Klebsiella sp. (five cases), Pseudomonas aeruginosa (five cases), Enterobacter aerogenes (three cases), Serratia marcescens (three cases) and others (seven cases). All but one of the bacteremic patients had received prior antibiotics, and 19 of 34 episodes were preceded by gentamicin therapy. Nine patients with bacteremia caused by the gentamicin-resistant strains received one to three weeks of amikacin therapy. All showed clinical improvement and the organism cleared from their bloodstreams; in one patient clinical deafness developed; in two patients bacterial suprainfections developed, and five patients subsequently died of other causes during their hospitalization." @default.
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• W2076899615 date "1977-06-01" @default.
• W2076899615 modified "2023-09-26" @default.
• W2076899615 title "Nosocomial bloodstream infections caused by gentamicin-resistant gram-negative bacilli" @default.
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• W2076899615 doi "https://doi.org/10.1016/0002-9343(77)90658-1" @default.
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