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- W2076899931 abstract "Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is an established procedure in the diagnosis of lesions of the gastrointestinal tract and of adjacent organs. However, the diagnostic yield of EUS-FNA depends on site and characteristics of target tissues as well as technical factors (type of needle, biopsy technique and material processing). The aim of this prospective multicenter study was to assess the feasibility and diagnostic accuracy of a newly developed 19G EUS histology needle. In 5 European centers 50 consecutive patients underwent a EUS-guided biopsy to evaluate intraintestinal or extraintestinal mass lesions and/or lymph nodes. All EUS procedures were done by experienced endosonographers using a convex array echoendoscope (Pentax EG-3870UTK®, Olympus UCT-140®). EUS fine needle biopsies (FNBs) were performed with the newly developed 19G needle (EchoTip ProCore needle, Cook Medical Inc, Limerick Ireland) using the same technique in all centers. Only a single pass was performed. The specimen was recovered in cytolit or formalin and processed for histological analysis. A dedicated local pathologist evaluated specimens in each individual center. The gold standard used to establish the final diagnosis was based on definite surgical pathology or clinical follow-up including repeated imaging examinations. A total of 50 patients were enrolled (median age 67.7). The indications were pancreatic masses(23), lymphnodes(16), submucosal lesions(6), abdominal masses(2), mediastinal mass(1), left liver lesion(1) and left adrenal gland(1). EUS-biopsy with the histology needle was technically feasible in all cases (100%). Adequate tissue samples for histological evaluation were obtained in 98% of cases (49/50). The final histologic diagnosis obtained with the 19G-ProCore needle was pancreatic adenocarcinoma(19), focal pancreatitis(1), GIST(4), leiomioma(3), neuroendocrine tumor(1), metastatic nodes(6), lymphoma(3), reactive nodes(6) including 1 sarcoidosis and 1 TB, epidermoid cancer(1), oat cell cancer(1) and liver metastasis(1). EUS-FNB was inconclusive in 3 cases with a suspicious of pancreatic cancer, in whom a second biopsy showed pancreatic adenocarcinoma in all cases. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy for the histologic diagnosis were 93.3%, 100%, 100%, 57.1% and 93.9% respectively. EUS-FNB using the new 19G ProCore needle provided adequate histological tissue samples in almost all cases (98%). Its overall accuracy with regard to the final gold standard diagnosis reached 94%. These promising results open up the possibility for a histological rather than the conventional cytological diagnosis when harvesting EUS guided tissue samples, including the application for immunohistochemistry for more accurate subtyping of lesions." @default.
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- W2076899931 date "2011-04-01" @default.
- W2076899931 modified "2023-10-18" @default.
- W2076899931 title "Sa1459 Feasibility and Accuracy of a New 19G EUS Hystology Needle: A Multicenter Prospective Study" @default.
- W2076899931 doi "https://doi.org/10.1016/j.gie.2011.03.193" @default.
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