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• W2076901360 abstract "Post-translational modifications such as phosphorylation provide versatile context-specific strategies for modulating transcription factor activity. In the prevailing view of this process, modifying enzymes indirectly influence gene expression by shuttling to and from the nucleus where they alter the activity of their target transcription factors. However, a new paradigm has recently been suggested from studies of Eyes absent (EYA), a member of a conserved network of transcriptional regulators implicated in the development of numerous tissues and organs including the eye, ear, muscle and kidney. These findings indicate that EYA operates both as a transcriptional coactivator and as the prototype of a novel class of protein tyrosine phosphatases. The regulatory potential of such a bifunctional transcription factor is enormous and suggests a new layer of dynamic regulation in which transcription factors themselves might provide intrinsic enzymatic activities to fine-tune nuclear output. Post-translational modifications such as phosphorylation provide versatile context-specific strategies for modulating transcription factor activity. In the prevailing view of this process, modifying enzymes indirectly influence gene expression by shuttling to and from the nucleus where they alter the activity of their target transcription factors. However, a new paradigm has recently been suggested from studies of Eyes absent (EYA), a member of a conserved network of transcriptional regulators implicated in the development of numerous tissues and organs including the eye, ear, muscle and kidney. These findings indicate that EYA operates both as a transcriptional coactivator and as the prototype of a novel class of protein tyrosine phosphatases. The regulatory potential of such a bifunctional transcription factor is enormous and suggests a new layer of dynamic regulation in which transcription factors themselves might provide intrinsic enzymatic activities to fine-tune nuclear output." @default.
• W2076901360 created "2016-06-24" @default.
• W2076901360 creator A5017028389 @default.
• W2076901360 creator A5033906250 @default.
• W2076901360 creator A5042569887 @default.
• W2076901360 date "2005-03-01" @default.
• W2076901360 modified "2023-10-12" @default.
• W2076901360 title "New vision from Eyes absent: transcription factors as enzymes" @default.
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• W2076901360 doi "https://doi.org/10.1016/j.tig.2005.01.005" @default.
• W2076901360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15734575" @default.
• W2076901360 hasPublicationYear "2005" @default.
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