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- W2076902549 abstract "The degradation rate of the polymer, poly(d,l-lactide), was accelerated in the presence of the tertiary amino compound, thioridazine. The poly(d,l-lactide) component of micro-capsules containing up to 50% thioridazine free base showed a decrease in molecular weight during microcapsule fabrication and in the course of dissolution-rate studies. This effect was evidenced on dissolution by an unexpectedly rapid release of thioridazine as a function of time. Polymer hydrolysis was neither appreciable in microcapsules containing no drug nor when the amino group of thioridazine was protonated in the form of the pamoate salt. This enhancement of degradation rate may be attributed to amine-influenced hydrolysis of poly(d,l-lactide). Thioridazine blood levels obtained from the microcapsules in dogs paralleled the in vitro results. There was an initial lag time followed by a rapid release of the drug producing blood levels over about a six-day span. Polymeric decomposition was also determined in vitro, pH 7.4, by gel-permeation chromatography. The results indicate a rapid molecular-weight decrease of the polymer, corroborating the in vivo and in vitro results." @default.
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- W2076902549 date "1986-01-01" @default.
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- W2076902549 title "Biodegradable microcapsules: Acceleration of polymeric excipient hydrolytic rate by incorporation of a basic medicament" @default.
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- W2076902549 doi "https://doi.org/10.1016/0168-3659(86)90071-4" @default.
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