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- W2076921944 abstract "Abstract Injections of 1 or 2 mg doses of cortisone, hydrocortisone, corticosterone or prednisolone into mice cause, 24 h after the injection a large decrease in weight of spleen and thymus which is accompanied by very large increases in the activity of the lysosomal acid phosphatase in these tissues. Prednisolone and hydrocortisone were most effective. Injection of testosterone, 11-hydroxyprogesterone and 17-hydroxyprogesterone had very little effect on the weight of the lymphoid tissues and caused only very small changes in the activity of lysosomal enzymes. These effects of the activating hormones are very similar to those previously observed following irradiation of the spleen or thymus with X-rays and it is considered that the lysosomal activation observed is mediated by lymphocytolysis and not by a direct effect of the steroids on the lysosomes" @default.
- W2076921944 created "2016-06-24" @default.
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- W2076921944 date "1978-02-01" @default.
- W2076921944 modified "2023-09-25" @default.
- W2076921944 title "The activation of lymphoid tissue lysosomal enzymes by steroid hormones" @default.
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- W2076921944 doi "https://doi.org/10.1016/0022-4731(78)90074-2" @default.
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