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- W2076931403 abstract "The effect of a convulsive agent, 3-amino-1-methyl-5H-pyridol[4,3-b]indole (Trp-P-2), on the GABA-induced chloride current (IC1) in dissociated mouse sensory neurons was investigated using the whole cell clamp method. Trp-P-2 reversibly suppressed the GABA-induced ICl in a dose-dependent manner. The IC50 for Trp-P-2 on the ICl evoked by 3 μM GABA was 11.1 μM. Ro15-1788 had no effect on the suppressive action of Trp-P-2. These results suggest that the observed effect of Trp-P-2 is mediated by its action as antagonist at GABAA receptors." @default.
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- W2076931403 date "1989-08-01" @default.
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- W2076931403 title "Suppression of GABA-induced chloride current by 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2)" @default.
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- W2076931403 doi "https://doi.org/10.1016/0014-2999(89)90375-0" @default.
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