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• W2076937197 abstract "Abstract. To determine if parathyroid hormone release in man is directly stimulated by glucocorticoids, dispersed human parathyroid cells from hyperplastic glands obtained from eight renal transplant recipients were studied in vitro. Dexamethasone (10 ‐11 to 10 ‐6 mol 1 ‐1 ) increased PTH release in a time‐ and dose‐dependent manner. A plateau was reached at 10 ‐8 mol 1 ‐1 (1015pM 149 vs. 230pM27 pg 10 ‐4 cells for control value, after 24 h incubation; P < 0.0001). An interaction with a glucocorticoid receptor was suggested since 10 ‐6 mol 1 ‐1 RU 486 blunted the dexamethasone‐induced PTH release. By Northern blot analysis, dexamethasone was found to increase the amount of preproPTH mRNA in these cells. The effect of dexamethasone was probably at the gene level since (1) 1,25 dihydroxy vitamin D 3 inhibited both iPTH and pre‐proPTH mRNA increases induced by dexamethasone and (2) alpha‐amanitin (1,25 μg ml ‐1 ) also completely suppressed the dexamethasone‐induced PTH release. Thus, for the first time, we demonstrate that dexamethasone induces an increase of PTH synthesis, probably by increasing PTH gene transcription. This effect may play an important pathogenic role in persisting hyper‐parathyroidism and steroid‐induced bone complications in renal transplant recipients.," @default.
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• W2076937197 date "1990-08-01" @default.
• W2076937197 modified "2023-10-18" @default.
• W2076937197 title "Dexamethasone increases preproparathyroid hormone messenger RNA in human hyperplastic parathyroid cells in vitro" @default.
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• W2076937197 doi "https://doi.org/10.1111/j.1365-2362.1990.tb01875.x" @default.
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