FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076943958> ?p ?o ?g. }

• W2076943958 endingPage "6264" @default.
• W2076943958 startingPage "6259" @default.
• W2076943958 abstract "Protein kinases play an important role in the maintenance of homeostasis between cell survival and apoptosis. Deregulation of these kinases leads to various pathological manifestations, such as cancer and neurodegenerative diseases. The MST1 encodes a serine/threonine kinase that is activated upon apoptotic stimulation, which in turn phosphorylates its downstream targets, Histone H2B and FOXO. However, the upstream regulators of MST1 kinase have been poorly studied. In this study, we report that JNK (c-Jun N-terminal kinase) phosphorylates MST1 at serine 82, which leads to the enhancement of MST1 activation. Accordingly, the activation of MST1 phosphorylates FOXO3 at serine 207 and promotes cell death. The inhibition of JNK kinase per se attenuates MST1 activity and nuclear translocation as well as MST1-induced apoptosis. We also find the S82A (serine mutated to alanine) diminishes MST1 activation and its effect on the FOXO transcription activity. Collectively, these findings define the novel feedback regulation of MST1 kinase activation by its putative substrate, JNK, with implication for our understanding of the signaling mechanism during cell death. Protein kinases play an important role in the maintenance of homeostasis between cell survival and apoptosis. Deregulation of these kinases leads to various pathological manifestations, such as cancer and neurodegenerative diseases. The MST1 encodes a serine/threonine kinase that is activated upon apoptotic stimulation, which in turn phosphorylates its downstream targets, Histone H2B and FOXO. However, the upstream regulators of MST1 kinase have been poorly studied. In this study, we report that JNK (c-Jun N-terminal kinase) phosphorylates MST1 at serine 82, which leads to the enhancement of MST1 activation. Accordingly, the activation of MST1 phosphorylates FOXO3 at serine 207 and promotes cell death. The inhibition of JNK kinase per se attenuates MST1 activity and nuclear translocation as well as MST1-induced apoptosis. We also find the S82A (serine mutated to alanine) diminishes MST1 activation and its effect on the FOXO transcription activity. Collectively, these findings define the novel feedback regulation of MST1 kinase activation by its putative substrate, JNK, with implication for our understanding of the signaling mechanism during cell death." @default.
• W2076943958 created "2016-06-24" @default.
• W2076943958 creator A5022508036 @default.
• W2076943958 creator A5025526214 @default.
• W2076943958 creator A5032534411 @default.
• W2076943958 creator A5058141916 @default.
• W2076943958 creator A5060969271 @default.
• W2076943958 creator A5081491205 @default.
• W2076943958 creator A5083028444 @default.
• W2076943958 creator A5089666742 @default.
• W2076943958 date "2010-02-01" @default.
• W2076943958 modified "2023-09-29" @default.
• W2076943958 title "c-Jun N-terminal Kinase Enhances MST1-mediated Pro-apoptotic Signaling through Phosphorylation at Serine 82" @default.
• W2076943958 cites W1965876049 @default.
• W2076943958 cites W1965991145 @default.
• W2076943958 cites W1966260994 @default.
• W2076943958 cites W1972138202 @default.
• W2076943958 cites W1974268113 @default.
• W2076943958 cites W1986559713 @default.
• W2076943958 cites W2005975355 @default.
• W2076943958 cites W2015157788 @default.
• W2076943958 cites W2017052599 @default.
• W2076943958 cites W2028813694 @default.
• W2076943958 cites W2032033134 @default.
• W2076943958 cites W2032189098 @default.
• W2076943958 cites W2032853143 @default.
• W2076943958 cites W2047669024 @default.
• W2076943958 cites W2056949306 @default.
• W2076943958 cites W2059440739 @default.
• W2076943958 cites W2067151543 @default.
• W2076943958 cites W2072372914 @default.
• W2076943958 cites W2073568903 @default.
• W2076943958 cites W2075352286 @default.
• W2076943958 cites W2083106714 @default.
• W2076943958 cites W2085197940 @default.
• W2076943958 cites W2107866321 @default.
• W2076943958 cites W2120646148 @default.
• W2076943958 cites W2123868590 @default.
• W2076943958 cites W2136283388 @default.
• W2076943958 cites W2162434225 @default.
• W2076943958 cites W2162993954 @default.
• W2076943958 cites W2167096785 @default.
• W2076943958 cites W2319382059 @default.
• W2076943958 doi "https://doi.org/10.1074/jbc.m109.038570" @default.
• W2076943958 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2825421" @default.
• W2076943958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20028971" @default.
• W2076943958 hasPublicationYear "2010" @default.
• W2076943958 type Work @default.
• W2076943958 sameAs 2076943958 @default.
• W2076943958 citedByCount "64" @default.
• W2076943958 countsByYear W20769439582012 @default.
• W2076943958 countsByYear W20769439582013 @default.
• W2076943958 countsByYear W20769439582014 @default.
• W2076943958 countsByYear W20769439582015 @default.
• W2076943958 countsByYear W20769439582016 @default.
• W2076943958 countsByYear W20769439582017 @default.
• W2076943958 countsByYear W20769439582018 @default.
• W2076943958 countsByYear W20769439582019 @default.
• W2076943958 countsByYear W20769439582020 @default.
• W2076943958 countsByYear W20769439582021 @default.
• W2076943958 countsByYear W20769439582022 @default.
• W2076943958 countsByYear W20769439582023 @default.
• W2076943958 crossrefType "journal-article" @default.
• W2076943958 hasAuthorship W2076943958A5022508036 @default.
• W2076943958 hasAuthorship W2076943958A5025526214 @default.
• W2076943958 hasAuthorship W2076943958A5032534411 @default.
• W2076943958 hasAuthorship W2076943958A5058141916 @default.
• W2076943958 hasAuthorship W2076943958A5060969271 @default.
• W2076943958 hasAuthorship W2076943958A5081491205 @default.
• W2076943958 hasAuthorship W2076943958A5083028444 @default.
• W2076943958 hasAuthorship W2076943958A5089666742 @default.
• W2076943958 hasBestOaLocation W20769439581 @default.
• W2076943958 hasConcept C11960822 @default.
• W2076943958 hasConcept C124160383 @default.
• W2076943958 hasConcept C137361374 @default.
• W2076943958 hasConcept C159479382 @default.
• W2076943958 hasConcept C184235292 @default.
• W2076943958 hasConcept C502942594 @default.
• W2076943958 hasConcept C82495950 @default.
• W2076943958 hasConcept C86803240 @default.
• W2076943958 hasConcept C90934575 @default.
• W2076943958 hasConcept C95444343 @default.
• W2076943958 hasConcept C97029542 @default.
• W2076943958 hasConceptScore W2076943958C11960822 @default.
• W2076943958 hasConceptScore W2076943958C124160383 @default.
• W2076943958 hasConceptScore W2076943958C137361374 @default.
• W2076943958 hasConceptScore W2076943958C159479382 @default.
• W2076943958 hasConceptScore W2076943958C184235292 @default.
• W2076943958 hasConceptScore W2076943958C502942594 @default.
• W2076943958 hasConceptScore W2076943958C82495950 @default.
• W2076943958 hasConceptScore W2076943958C86803240 @default.
• W2076943958 hasConceptScore W2076943958C90934575 @default.
• W2076943958 hasConceptScore W2076943958C95444343 @default.
• W2076943958 hasConceptScore W2076943958C97029542 @default.
• W2076943958 hasIssue "9" @default.
• W2076943958 hasLocation W20769439581 @default.
• W2076943958 hasLocation W20769439582 @default.
• W2076943958 hasLocation W20769439583 @default.

• next