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• W2076944048 abstract "A series of phenylpiperazine derivatives were synthesized and evaluated for their neuropeptide Y (NPY) Y5 receptor antagonistic activities. The benzindane portion of 2 was replaced by 1-phenylpiperazine, resulting in novel urea derivative 3f. Subsequent optimization of the phenylpiperazine template by substitution of the phenyl moiety resulted in a series of (2-methanesulfonamidephenyl)piperazine derivatives that showed potent binding affinity and antagonistic activity for the Y5 receptor." @default.
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• W2076944048 date "2006-11-01" @default.
• W2076944048 modified "2023-09-26" @default.
• W2076944048 title "Novel potent neuropeptide Y Y5 receptor antagonists: Synthesis and structure–activity relationships of phenylpiperazine derivatives" @default.
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• W2076944048 doi "https://doi.org/10.1016/j.bmc.2006.07.023" @default.
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