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- W2076947983 abstract "When host defence mechanisms are stimulated there is a concomitant decrease in cytochrome P450 based drug biotransformation and elimination. This has resulted in a number of clinically important unwanted drug responses in patients with infections or inflammatory responses. The loss in cytochrome P450 is predominantly an effect at the level of the gene expression and the majority of enzyme forms examined to date are involved. Although the effect occurs predominantly in the liver it has been recently shown that inflammatory responses in the brain also cause a loss of the same enzyme forms in that organ. The loss of cytochrome P450 in the brain in response to localised inflammation is accompanied by a similar loss in the liver. The decrease of cytochrome P450 and its dependent drug biotransformation is of concern whenever drugs are used in patients with infections or disease states with an inflammatory component." @default.
- W2076947983 created "2016-06-24" @default.
- W2076947983 creator A5039492959 @default.
- W2076947983 date "2000-01-01" @default.
- W2076947983 modified "2023-09-23" @default.
- W2076947983 title "Hepatic drug metabolism and immunostimulation" @default.
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- W2076947983 doi "https://doi.org/10.1016/s0300-483x(99)00142-0" @default.
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