Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076953879> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2076953879 endingPage "632" @default.
- W2076953879 startingPage "631" @default.
- W2076953879 abstract "Cancer cells bypass replicative senescence, the major barrier to tumor progression, by using telomerase or alternative lengthening of telomeres (ALT) as telomere maintenance mechanisms (TMMs). Correlation between ALT and patient survival was demonstrated for high-grade astrocytomas. Transcription from subtelomeres produces telomeric repeat-containing RNA (TERRA), a natural inhibitor of telomerase activity (TA). This led us to evaluate correlations of TERRA and TMM with tumor grade and outcome in astrocytoma patients. SYBR Green real-time reverse transcription-polymerase chain reaction assays for quantitation of total and chromosome 2p and 18p specific TERRA levels were developed. Tumor samples from 46 patients with astrocytoma grade 2 to 4, tissue controls, and cell lines were assessed. TMMs were evaluated by measuring TA and by detecting long telomeres due to ALT. In glioblastoma multiforme (GBM) grade 4, total TERRA levels were similar to cell lines but 14-, 31-, and 313-fold lower compared with grade 3, grade 2, and nonmalignant tissue, respectively. Total TERRA levels differed from chromosomal levels. Low 2p TERRA levels correlated with dense promoter methylation of subtelomeric CpG islands, indicating that TERRA expression in gliomas may be chromosome specific and epigenetically regulated. Total TERRA levels correlated with diagnosis, with low or absent TA and the presence of ALT, and were tentatively associated with favorable patient prognosis in our cohort (P = .06). TA and short telomeres identified a subset of GBM with a median survival of only 14.8 months. TERRA and TA may be prognostic in astrocytic tumors." @default.
- W2076953879 created "2016-06-24" @default.
- W2076953879 creator A5000439421 @default.
- W2076953879 creator A5048428897 @default.
- W2076953879 date "2012-05-01" @default.
- W2076953879 modified "2023-10-14" @default.
- W2076953879 title "Giant Intracranial Tumors: A Neurosurgical Challenge" @default.
- W2076953879 cites W1493555182 @default.
- W2076953879 cites W1538159989 @default.
- W2076953879 cites W1608858333 @default.
- W2076953879 cites W1986253681 @default.
- W2076953879 cites W1994021892 @default.
- W2076953879 cites W1998988948 @default.
- W2076953879 cites W2043216047 @default.
- W2076953879 cites W2080509551 @default.
- W2076953879 cites W2141965159 @default.
- W2076953879 cites W2165254481 @default.
- W2076953879 cites W2419633439 @default.
- W2076953879 doi "https://doi.org/10.1016/j.wneu.2011.11.012" @default.
- W2076953879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22381327" @default.
- W2076953879 hasPublicationYear "2012" @default.
- W2076953879 type Work @default.
- W2076953879 sameAs 2076953879 @default.
- W2076953879 citedByCount "3" @default.
- W2076953879 countsByYear W20769538792014 @default.
- W2076953879 countsByYear W20769538792015 @default.
- W2076953879 countsByYear W20769538792020 @default.
- W2076953879 crossrefType "journal-article" @default.
- W2076953879 hasAuthorship W2076953879A5000439421 @default.
- W2076953879 hasAuthorship W2076953879A5048428897 @default.
- W2076953879 hasConcept C104317684 @default.
- W2076953879 hasConcept C121608353 @default.
- W2076953879 hasConcept C126322002 @default.
- W2076953879 hasConcept C142724271 @default.
- W2076953879 hasConcept C143998085 @default.
- W2076953879 hasConcept C150194340 @default.
- W2076953879 hasConcept C177336024 @default.
- W2076953879 hasConcept C23069440 @default.
- W2076953879 hasConcept C2778227246 @default.
- W2076953879 hasConcept C2778880634 @default.
- W2076953879 hasConcept C2779256057 @default.
- W2076953879 hasConcept C4692481 @default.
- W2076953879 hasConcept C502942594 @default.
- W2076953879 hasConcept C54355233 @default.
- W2076953879 hasConcept C71924100 @default.
- W2076953879 hasConcept C86803240 @default.
- W2076953879 hasConcept C94581717 @default.
- W2076953879 hasConceptScore W2076953879C104317684 @default.
- W2076953879 hasConceptScore W2076953879C121608353 @default.
- W2076953879 hasConceptScore W2076953879C126322002 @default.
- W2076953879 hasConceptScore W2076953879C142724271 @default.
- W2076953879 hasConceptScore W2076953879C143998085 @default.
- W2076953879 hasConceptScore W2076953879C150194340 @default.
- W2076953879 hasConceptScore W2076953879C177336024 @default.
- W2076953879 hasConceptScore W2076953879C23069440 @default.
- W2076953879 hasConceptScore W2076953879C2778227246 @default.
- W2076953879 hasConceptScore W2076953879C2778880634 @default.
- W2076953879 hasConceptScore W2076953879C2779256057 @default.
- W2076953879 hasConceptScore W2076953879C4692481 @default.
- W2076953879 hasConceptScore W2076953879C502942594 @default.
- W2076953879 hasConceptScore W2076953879C54355233 @default.
- W2076953879 hasConceptScore W2076953879C71924100 @default.
- W2076953879 hasConceptScore W2076953879C86803240 @default.
- W2076953879 hasConceptScore W2076953879C94581717 @default.
- W2076953879 hasIssue "5-6" @default.
- W2076953879 hasLocation W20769538791 @default.
- W2076953879 hasLocation W20769538792 @default.
- W2076953879 hasOpenAccess W2076953879 @default.
- W2076953879 hasPrimaryLocation W20769538791 @default.
- W2076953879 hasRelatedWork W1621602741 @default.
- W2076953879 hasRelatedWork W1966524413 @default.
- W2076953879 hasRelatedWork W1989113088 @default.
- W2076953879 hasRelatedWork W2037053816 @default.
- W2076953879 hasRelatedWork W2079169697 @default.
- W2076953879 hasRelatedWork W2091699981 @default.
- W2076953879 hasRelatedWork W2147039165 @default.
- W2076953879 hasRelatedWork W2793039347 @default.
- W2076953879 hasRelatedWork W3199533915 @default.
- W2076953879 hasRelatedWork W4285085774 @default.
- W2076953879 hasVolume "77" @default.
- W2076953879 isParatext "false" @default.
- W2076953879 isRetracted "false" @default.
- W2076953879 magId "2076953879" @default.
- W2076953879 workType "article" @default.