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- W2076972005 abstract "PI3Kgamma is a phosphoinositide 3-kinase characterized by both lipid and protein kinase activity. It is activated by G-protein-coupled receptors and is predominantly expressed in leucocytes; in addition, recent work showed its presence in the heart and its involvement in regulating cardiac functions. In this tissue, PI3Kgamma acts as a negative modulator of contractility, by decreasing cAMP concentration through a kinase-independent mechanism. Indeed, whereas PI3Kgamma-deficient mice show an abnormal cAMP elevation, cAMP levels in knock-in mouse mutants, expressing a kinase-dead PI3Kgamma, are comparable with wild-type controls. PI3Kgamma regulates cardiac cAMP homoeostasis by forming a macromolecular complex containing PDE3B (phosphodiesterase 3B). In this complex, PI3Kgamma could regulate PDE3B activity through protein kinase A, a PDE activator." @default.
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- W2076972005 date "2006-07-21" @default.
- W2076972005 modified "2023-09-27" @default.
- W2076972005 title "Identification of the macromolecular complex responsible for PI3Kγ-dependent regulation of cAMP levels" @default.
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- W2076972005 doi "https://doi.org/10.1042/bst0340502" @default.
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