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• W2076974089 abstract "The prognostic variables of 281 women with breast carcinoma (followed up for more than 8 years) were studied using Cox's analysis. Clinical and histologic features, nuclear morphometric variables, and mitotic indices were analyzed separately in progesterone receptor-negative (PR-) and -positive tumors (PR+). In PR- tumors, axillary lymph node status (p=0.0025) and tumor size (p=0.03) were predictors of survival in the univariate analysis. Tumor size (p<0.0001), axillary lymph node status (p=0.0006), the volume-corrected mitotic index (M/V index) (p=0.0023), and the mitotic activity index (MAI) (p=0.0067) were found to be related to survival according to univariate analysis of PR+ tumors. In PR- tumors, axillary lymph node status (p=0.002), year of treatment (p=0.017), and circumscription of the tumor margin (p=0.02) had independent predictive value. In PR+ tumors, tumor size (p<0.001), the MAI (p=0.001), and axillary lymph node status (p=0.04) predicted survival independently in Cox's analysis. In PR- tumors, histologic type (p=0.008) was an independent predictor of recurrence-free survival, whereas in PR+ tumors, the M/V index (p<0.001), tumor size (p=0.007), and the standard deviation of the nuclear perimeter (p=0.026) were independently related to recurrence-free survival. The results indicated that mitotic indices and nuclear morphometric variables are of limited value in predicting patient survival in breast carcinomas that are hormone receptor negative. Thus, a separate analysis is advocated for hormone receptor-positive and-negative tumors when the predictive value of quantitative measurements and histologic variables is tested in patients with breast cancer. The prognostic variables of 281 women with breast carcinoma (followed up for more than 8 years) were studied using Cox's analysis. Clinical and histologic features, nuclear morphometric variables, and mitotic indices were analyzed separately in progesterone receptor-negative (PR-) and -positive tumors (PR+). In PR- tumors, axillary lymph node status (p=0.0025) and tumor size (p=0.03) were predictors of survival in the univariate analysis. Tumor size (p<0.0001), axillary lymph node status (p=0.0006), the volume-corrected mitotic index (M/V index) (p=0.0023), and the mitotic activity index (MAI) (p=0.0067) were found to be related to survival according to univariate analysis of PR+ tumors. In PR- tumors, axillary lymph node status (p=0.002), year of treatment (p=0.017), and circumscription of the tumor margin (p=0.02) had independent predictive value. In PR+ tumors, tumor size (p<0.001), the MAI (p=0.001), and axillary lymph node status (p=0.04) predicted survival independently in Cox's analysis. In PR- tumors, histologic type (p=0.008) was an independent predictor of recurrence-free survival, whereas in PR+ tumors, the M/V index (p<0.001), tumor size (p=0.007), and the standard deviation of the nuclear perimeter (p=0.026) were independently related to recurrence-free survival. The results indicated that mitotic indices and nuclear morphometric variables are of limited value in predicting patient survival in breast carcinomas that are hormone receptor negative. Thus, a separate analysis is advocated for hormone receptor-positive and-negative tumors when the predictive value of quantitative measurements and histologic variables is tested in patients with breast cancer." @default.
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• W2076974089 date "1993-03-01" @default.
• W2076974089 modified "2023-10-17" @default.
• W2076974089 title "Comparison of classic and quantitative prognostic factors in hormone receptor-positive and hormone receptor-negative female breast cancer" @default.
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• W2076974089 doi "https://doi.org/10.1016/s0002-9610(05)80831-1" @default.
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