FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076975178> ?p ?o ?g. }

• W2076975178 endingPage "243" @default.
• W2076975178 startingPage "238" @default.
• W2076975178 abstract "Empirical use of fluoroquinolones (FQ) to treat a variety of bacterial infections may inadvertently select for FQ-resistant strains of Mycobacterium tuberculosis(MTB), especially in rural China where the use of FQ in treating infections has not been standardized. Here we determine the prevalence and describe the transmission of FQ-resistant MTB in two rural counties in eastern China through a combination of conventional epidemiology with IS6110-based restriction fragment length polymorphism(RFLP) analysis and DNA sequencing of drug-resistance determining regions. Phenotypic FQ resistance was detected in 31 of 351(8.8%) isolates. FQ resistance was equally distributed between patient-isolates deemed drug resistant and drug-susceptible, but mostly observed in those with treatment history of respiratory infection. Mutations in gyrA were found in 54.8% of FQ resistant isolates, and one isolate with a gyrB mutation. Despite predominating in entire bacilli population(69.2%), Beijing family strain had similar proportion of FQ resistance to the other(10.3% vs. 4.7%, p = 0.060). IS6110RFLP identified 2 clusters(4 isolates) among FQ resistant isolates and 3 clusters composed of both 4 FQ resistant isolates and 6 FQ susceptible isolates. Our results indicate that FQ-resistant MTB has emerged among the circulating bacillary population in rural eastern China. The relatively low level of clustering among FQ-resistant strains suggests most are acquired de novo, likely due to widespread FQ use." @default.
• W2076975178 created "2016-06-24" @default.
• W2076975178 creator A5027201038 @default.
• W2076975178 creator A5028667300 @default.
• W2076975178 creator A5031491320 @default.
• W2076975178 creator A5038764472 @default.
• W2076975178 creator A5044485195 @default.
• W2076975178 creator A5091577136 @default.
• W2076975178 date "2011-05-01" @default.
• W2076975178 modified "2023-09-22" @default.
• W2076975178 title "Population-based investigation of fluoroquinolones resistant tuberculosis in rural eastern China" @default.
• W2076975178 cites W1976141072 @default.
• W2076975178 cites W1999298441 @default.
• W2076975178 cites W2007815895 @default.
• W2076975178 cites W2008858822 @default.
• W2076975178 cites W2036934210 @default.
• W2076975178 cites W2039170919 @default.
• W2076975178 cites W2055305897 @default.
• W2076975178 cites W2057498351 @default.
• W2076975178 cites W2063296793 @default.
• W2076975178 cites W2076536619 @default.
• W2076975178 cites W2082508590 @default.
• W2076975178 cites W2100887397 @default.
• W2076975178 cites W2107861076 @default.
• W2076975178 cites W2109147740 @default.
• W2076975178 cites W2117034387 @default.
• W2076975178 cites W2134276472 @default.
• W2076975178 cites W2134535764 @default.
• W2076975178 cites W2142392294 @default.
• W2076975178 cites W2170172427 @default.
• W2076975178 cites W2171372087 @default.
• W2076975178 cites W2321267821 @default.
• W2076975178 cites W2418210342 @default.
• W2076975178 doi "https://doi.org/10.1016/j.tube.2011.03.001" @default.
• W2076975178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21450523" @default.
• W2076975178 hasPublicationYear "2011" @default.
• W2076975178 type Work @default.
• W2076975178 sameAs 2076975178 @default.
• W2076975178 citedByCount "13" @default.
• W2076975178 countsByYear W20769751782012 @default.
• W2076975178 countsByYear W20769751782013 @default.
• W2076975178 countsByYear W20769751782015 @default.
• W2076975178 countsByYear W20769751782019 @default.
• W2076975178 countsByYear W20769751782020 @default.
• W2076975178 countsByYear W20769751782022 @default.
• W2076975178 crossrefType "journal-article" @default.
• W2076975178 hasAuthorship W2076975178A5027201038 @default.
• W2076975178 hasAuthorship W2076975178A5028667300 @default.
• W2076975178 hasAuthorship W2076975178A5031491320 @default.
• W2076975178 hasAuthorship W2076975178A5038764472 @default.
• W2076975178 hasAuthorship W2076975178A5044485195 @default.
• W2076975178 hasAuthorship W2076975178A5091577136 @default.
• W2076975178 hasConcept C104317684 @default.
• W2076975178 hasConcept C114851261 @default.
• W2076975178 hasConcept C135763542 @default.
• W2076975178 hasConcept C142724271 @default.
• W2076975178 hasConcept C159047783 @default.
• W2076975178 hasConcept C168007829 @default.
• W2076975178 hasConcept C2777975735 @default.
• W2076975178 hasConcept C2781069245 @default.
• W2076975178 hasConcept C2908647359 @default.
• W2076975178 hasConcept C42972112 @default.
• W2076975178 hasConcept C54355233 @default.
• W2076975178 hasConcept C71924100 @default.
• W2076975178 hasConcept C86803240 @default.
• W2076975178 hasConcept C89423630 @default.
• W2076975178 hasConcept C99454951 @default.
• W2076975178 hasConceptScore W2076975178C104317684 @default.
• W2076975178 hasConceptScore W2076975178C114851261 @default.
• W2076975178 hasConceptScore W2076975178C135763542 @default.
• W2076975178 hasConceptScore W2076975178C142724271 @default.
• W2076975178 hasConceptScore W2076975178C159047783 @default.
• W2076975178 hasConceptScore W2076975178C168007829 @default.
• W2076975178 hasConceptScore W2076975178C2777975735 @default.
• W2076975178 hasConceptScore W2076975178C2781069245 @default.
• W2076975178 hasConceptScore W2076975178C2908647359 @default.
• W2076975178 hasConceptScore W2076975178C42972112 @default.
• W2076975178 hasConceptScore W2076975178C54355233 @default.
• W2076975178 hasConceptScore W2076975178C71924100 @default.
• W2076975178 hasConceptScore W2076975178C86803240 @default.
• W2076975178 hasConceptScore W2076975178C89423630 @default.
• W2076975178 hasConceptScore W2076975178C99454951 @default.
• W2076975178 hasIssue "3" @default.
• W2076975178 hasLocation W20769751781 @default.
• W2076975178 hasLocation W20769751782 @default.
• W2076975178 hasOpenAccess W2076975178 @default.
• W2076975178 hasPrimaryLocation W20769751781 @default.
• W2076975178 hasRelatedWork W11484398 @default.
• W2076975178 hasRelatedWork W1911256344 @default.
• W2076975178 hasRelatedWork W1991577656 @default.
• W2076975178 hasRelatedWork W2000067139 @default.
• W2076975178 hasRelatedWork W2002134710 @default.
• W2076975178 hasRelatedWork W2008162475 @default.
• W2076975178 hasRelatedWork W2010039267 @default.
• W2076975178 hasRelatedWork W2048767428 @default.
• W2076975178 hasRelatedWork W2058938718 @default.
• W2076975178 hasRelatedWork W2059116761 @default.
• W2076975178 hasRelatedWork W2076536619 @default.

• next