Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076983776> ?p ?o ?g. }
- W2076983776 endingPage "47" @default.
- W2076983776 startingPage "37" @default.
- W2076983776 abstract "Reversible, covalent modification with small ubiquitin-related modifier proteins (SUMOs) is known to mediate nuclear import/export and activity of transcription factors. Here, the SUMO pathway is shown to operate at the plasma membrane to control ion channel function. SUMO-conjugating enzyme is seen to be resident in plasma membrane, to assemble with K2P1, and to modify K2P1 lysine 274. K2P1 had not previously shown function despite mRNA expression in heart, brain, and kidney and sequence features like other two-P loop K+ leak (K2P) pores that control activity of excitable cells. Removal of the peptide adduct by SUMO protease reveals K2P1 to be a K+-selective, pH-sensitive, openly rectifying channel regulated by reversible peptide linkage." @default.
- W2076983776 created "2016-06-24" @default.
- W2076983776 creator A5005647963 @default.
- W2076983776 creator A5007736608 @default.
- W2076983776 creator A5021498481 @default.
- W2076983776 creator A5041473178 @default.
- W2076983776 creator A5060523759 @default.
- W2076983776 date "2005-04-01" @default.
- W2076983776 modified "2023-10-14" @default.
- W2076983776 title "Sumoylation Silences the Plasma Membrane Leak K+ Channel K2P1" @default.
- W2076983776 cites W1482320560 @default.
- W2076983776 cites W1530042671 @default.
- W2076983776 cites W1602588988 @default.
- W2076983776 cites W1798638058 @default.
- W2076983776 cites W1970403861 @default.
- W2076983776 cites W1976365446 @default.
- W2076983776 cites W1981611457 @default.
- W2076983776 cites W1984405912 @default.
- W2076983776 cites W1985940938 @default.
- W2076983776 cites W1986644095 @default.
- W2076983776 cites W1987556650 @default.
- W2076983776 cites W1991189921 @default.
- W2076983776 cites W1993637697 @default.
- W2076983776 cites W1999054610 @default.
- W2076983776 cites W2001238464 @default.
- W2076983776 cites W2004214053 @default.
- W2076983776 cites W2011116990 @default.
- W2076983776 cites W2015595533 @default.
- W2076983776 cites W2020129304 @default.
- W2076983776 cites W2025886346 @default.
- W2076983776 cites W2031211051 @default.
- W2076983776 cites W2033850732 @default.
- W2076983776 cites W2040672638 @default.
- W2076983776 cites W2043702719 @default.
- W2076983776 cites W2053242498 @default.
- W2076983776 cites W2055038470 @default.
- W2076983776 cites W2056880507 @default.
- W2076983776 cites W2056883829 @default.
- W2076983776 cites W2070163476 @default.
- W2076983776 cites W2074760482 @default.
- W2076983776 cites W2077704784 @default.
- W2076983776 cites W2077822870 @default.
- W2076983776 cites W2083312621 @default.
- W2076983776 cites W2084117490 @default.
- W2076983776 cites W2087787002 @default.
- W2076983776 cites W2094423062 @default.
- W2076983776 cites W2097400197 @default.
- W2076983776 cites W2110548948 @default.
- W2076983776 cites W2122044343 @default.
- W2076983776 cites W2147142035 @default.
- W2076983776 cites W2153569873 @default.
- W2076983776 cites W2154805387 @default.
- W2076983776 cites W2469938121 @default.
- W2076983776 cites W2791163698 @default.
- W2076983776 cites W3843308 @default.
- W2076983776 cites W4234029139 @default.
- W2076983776 cites W59088806 @default.
- W2076983776 doi "https://doi.org/10.1016/j.cell.2005.01.019" @default.
- W2076983776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15820677" @default.
- W2076983776 hasPublicationYear "2005" @default.
- W2076983776 type Work @default.
- W2076983776 sameAs 2076983776 @default.
- W2076983776 citedByCount "242" @default.
- W2076983776 countsByYear W20769837762012 @default.
- W2076983776 countsByYear W20769837762013 @default.
- W2076983776 countsByYear W20769837762014 @default.
- W2076983776 countsByYear W20769837762015 @default.
- W2076983776 countsByYear W20769837762016 @default.
- W2076983776 countsByYear W20769837762017 @default.
- W2076983776 countsByYear W20769837762018 @default.
- W2076983776 countsByYear W20769837762019 @default.
- W2076983776 countsByYear W20769837762020 @default.
- W2076983776 countsByYear W20769837762021 @default.
- W2076983776 countsByYear W20769837762022 @default.
- W2076983776 countsByYear W20769837762023 @default.
- W2076983776 crossrefType "journal-article" @default.
- W2076983776 hasAuthorship W2076983776A5005647963 @default.
- W2076983776 hasAuthorship W2076983776A5007736608 @default.
- W2076983776 hasAuthorship W2076983776A5021498481 @default.
- W2076983776 hasAuthorship W2076983776A5041473178 @default.
- W2076983776 hasAuthorship W2076983776A5060523759 @default.
- W2076983776 hasBestOaLocation W20769837761 @default.
- W2076983776 hasConcept C104317684 @default.
- W2076983776 hasConcept C12554922 @default.
- W2076983776 hasConcept C144519050 @default.
- W2076983776 hasConcept C153911025 @default.
- W2076983776 hasConcept C170493617 @default.
- W2076983776 hasConcept C171350616 @default.
- W2076983776 hasConcept C181199279 @default.
- W2076983776 hasConcept C25602115 @default.
- W2076983776 hasConcept C2776016237 @default.
- W2076983776 hasConcept C2776714187 @default.
- W2076983776 hasConcept C2779281246 @default.
- W2076983776 hasConcept C41625074 @default.
- W2076983776 hasConcept C50254741 @default.
- W2076983776 hasConcept C515207424 @default.
- W2076983776 hasConcept C55493867 @default.
- W2076983776 hasConcept C86803240 @default.