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- W2076985239 abstract "<h2>Abstract</h2> A group of 10 women were treated with 100 mg of intravaginal prostaglandin F<sub>2α</sub> (PGF<sub>2α</sub>) as the THAM salt in the form of lactose tablets for one or two days in the mid-luteal phase of the menstrual cycle. Eight of the women were also treated with injections of human chorionic gonadotrophin (HCG) in order to mimic HCG production from an implanting embryo. Serum luteinizing hormone (LH) and progesterone levels were measured by radioimmunoassay and were correlated with the onset of the menstrual period. In all 10 women, PGF<sub>2α</sub> in the dosages given did not shorten the time interval between the LH peak and the onset of menses when compared to their untreated control cycles or to previous cycles artificially lengthened by HCG. In addition, there was no significant difference in serum progesterone between PGF<sub>2α</sub> treatment cycles and control cycles with or without HCG. During treatment, 9 of the 10 women had objectionable side-effects including diarrhea, abdominal cramping pain, pelvic pressure, nausea and vomiting. These data suggest that intravaginal PGF<sub>2α</sub> in the dosage and formulation used was systemically absorbed but had no luteolytic effects." @default.
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- W2076985239 date "1972-12-01" @default.
- W2076985239 modified "2023-09-27" @default.
- W2076985239 title "Fertility regulation with cyclic luteal phase vaginal administration of prostaglandin F2α" @default.
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- W2076985239 doi "https://doi.org/10.1016/s0010-7824(72)80012-x" @default.
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