FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076985488> ?p ?o ?g. }

• W2076985488 endingPage "620" @default.
• W2076985488 startingPage "616" @default.
• W2076985488 abstract "The purpose of the study was to determine whether paclitaxel inhibits the expression of heat shock protein 27 (HSP27) in two gynecologic cancer cell lines compared with other antineoplastic agents having different cytotoxic mechanisms. BG-1 ovarian cancer cells and HeLa uterine cancer cells were treated with a tubulin depolymerization inhibitor (paclitaxel), a topoisomerase-II inhibitor (etoposide), and two tubulin polymerization inhibitors (colcemid and vincristine). Cell kills were evaluated by counting the number of cells. Propidium iodide staining and flow cytometric analysis were applied for the determination of cell-cycle perturbation. HSP27 was stained by the indirect immunofluorescence technique and analyzed with a flow cytometer. In both BG-1 and HeLa cells, growth arrest and G2 / M accumulation were dependent on the dose of each cytotoxic agent. There were positive correlations between HSP27 overexpression and growth arrest and G2 / M accumulation when the cell lines were treated with etoposide, colcemid, or vincristine, but not with paclitaxel. Paclitaxel completely inhibited the expression of HSP27. The results of this study indicated that paclitaxel may possess unique mechanisms able to overcome drug resistance by inhibiting HSP27 expression." @default.
• W2076985488 created "2016-06-24" @default.
• W2076985488 creator A5025271372 @default.
• W2076985488 creator A5028272811 @default.
• W2076985488 creator A5056921218 @default.
• W2076985488 creator A5070457535 @default.
• W2076985488 creator A5081056671 @default.
• W2076985488 date "2004-07-01" @default.
• W2076985488 modified "2023-10-14" @default.
• W2076985488 title "Paclitaxel inhibits expression of heat shock protein 27 in ovarian and uterine cancer cells" @default.
• W2076985488 cites W1952459948 @default.
• W2076985488 cites W1974886740 @default.
• W2076985488 cites W1994445799 @default.
• W2076985488 cites W1994510190 @default.
• W2076985488 cites W2007501972 @default.
• W2076985488 cites W2046372528 @default.
• W2076985488 cites W2057355141 @default.
• W2076985488 cites W2076813962 @default.
• W2076985488 cites W2084937618 @default.
• W2076985488 cites W2089766373 @default.
• W2076985488 cites W2097105130 @default.
• W2076985488 cites W2105903567 @default.
• W2076985488 cites W2112989848 @default.
• W2076985488 cites W2113396371 @default.
• W2076985488 cites W2142385577 @default.
• W2076985488 cites W2313972632 @default.
• W2076985488 cites W2328421677 @default.
• W2076985488 cites W2329224618 @default.
• W2076985488 cites W4253691917 @default.
• W2076985488 doi "https://doi.org/10.1111/j.1048-891x.2004.14409.x" @default.
• W2076985488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15304155" @default.
• W2076985488 hasPublicationYear "2004" @default.
• W2076985488 type Work @default.
• W2076985488 sameAs 2076985488 @default.
• W2076985488 citedByCount "42" @default.
• W2076985488 countsByYear W20769854882012 @default.
• W2076985488 countsByYear W20769854882013 @default.
• W2076985488 countsByYear W20769854882014 @default.
• W2076985488 countsByYear W20769854882015 @default.
• W2076985488 countsByYear W20769854882016 @default.
• W2076985488 countsByYear W20769854882017 @default.
• W2076985488 countsByYear W20769854882019 @default.
• W2076985488 countsByYear W20769854882020 @default.
• W2076985488 countsByYear W20769854882022 @default.
• W2076985488 countsByYear W20769854882023 @default.
• W2076985488 crossrefType "journal-article" @default.
• W2076985488 hasAuthorship W2076985488A5025271372 @default.
• W2076985488 hasAuthorship W2076985488A5028272811 @default.
• W2076985488 hasAuthorship W2076985488A5056921218 @default.
• W2076985488 hasAuthorship W2076985488A5070457535 @default.
• W2076985488 hasAuthorship W2076985488A5081056671 @default.
• W2076985488 hasConcept C104317684 @default.
• W2076985488 hasConcept C121608353 @default.
• W2076985488 hasConcept C126322002 @default.
• W2076985488 hasConcept C142669718 @default.
• W2076985488 hasConcept C1491633281 @default.
• W2076985488 hasConcept C153911025 @default.
• W2076985488 hasConcept C154317977 @default.
• W2076985488 hasConcept C190283241 @default.
• W2076985488 hasConcept C202751555 @default.
• W2076985488 hasConcept C205260736 @default.
• W2076985488 hasConcept C2775934118 @default.
• W2076985488 hasConcept C2776095844 @default.
• W2076985488 hasConcept C2776694085 @default.
• W2076985488 hasConcept C2776755627 @default.
• W2076985488 hasConcept C2777292972 @default.
• W2076985488 hasConcept C2777366897 @default.
• W2076985488 hasConcept C2778119113 @default.
• W2076985488 hasConcept C2779363559 @default.
• W2076985488 hasConcept C2779429289 @default.
• W2076985488 hasConcept C2779559962 @default.
• W2076985488 hasConcept C2780427987 @default.
• W2076985488 hasConcept C31573885 @default.
• W2076985488 hasConcept C502942594 @default.
• W2076985488 hasConcept C55493867 @default.
• W2076985488 hasConcept C68991219 @default.
• W2076985488 hasConcept C71924100 @default.
• W2076985488 hasConcept C86803240 @default.
• W2076985488 hasConcept C96232424 @default.
• W2076985488 hasConceptScore W2076985488C104317684 @default.
• W2076985488 hasConceptScore W2076985488C121608353 @default.
• W2076985488 hasConceptScore W2076985488C126322002 @default.
• W2076985488 hasConceptScore W2076985488C142669718 @default.
• W2076985488 hasConceptScore W2076985488C1491633281 @default.
• W2076985488 hasConceptScore W2076985488C153911025 @default.
• W2076985488 hasConceptScore W2076985488C154317977 @default.
• W2076985488 hasConceptScore W2076985488C190283241 @default.
• W2076985488 hasConceptScore W2076985488C202751555 @default.
• W2076985488 hasConceptScore W2076985488C205260736 @default.
• W2076985488 hasConceptScore W2076985488C2775934118 @default.
• W2076985488 hasConceptScore W2076985488C2776095844 @default.
• W2076985488 hasConceptScore W2076985488C2776694085 @default.
• W2076985488 hasConceptScore W2076985488C2776755627 @default.
• W2076985488 hasConceptScore W2076985488C2777292972 @default.
• W2076985488 hasConceptScore W2076985488C2777366897 @default.
• W2076985488 hasConceptScore W2076985488C2778119113 @default.
• W2076985488 hasConceptScore W2076985488C2779363559 @default.
• W2076985488 hasConceptScore W2076985488C2779429289 @default.

• next